Wang Jiexin, Liu Maohui, Wen Lingmiao, Xing Pengfei, Chen Jiawei, Xia Xiuwen, Ding WeiJun
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Immunol. 2025 Jul 3;16:1598804. doi: 10.3389/fimmu.2025.1598804. eCollection 2025.
Obesity is a common metabolic syndrome in which an imbalance between energy intake and consumption is the main cause of excessive accumulation of body fat. The increasing prevalence of obesity and its associated complications poses significant challenges to public health. Activation of the transient receptor potential vanilloid subtype 1 (TRPV1) cascade plays a key role in lipid metabolism and energy intake. TRPV1 is expressed across the central nervous system and peripheral organs is involved in the regulation of hormone secretion, appetite and mitochondrial function, and is recognized as one of the key targets for preventing obesity. The current treatments for obesity exhibit limited efficacy and are associated with numerous side effects. Targeting TRPV1 represents a potentially effective approach for managing obesity. In this work, by combining the recent mechanism of the role of TRPV1 in neuroendocrine regulation, we hope to provide novel approaches to block or even reverse the development of obesity.
肥胖是一种常见的代谢综合征，其中能量摄入与消耗之间的失衡是体内脂肪过度堆积的主要原因。肥胖及其相关并发症的患病率不断上升，给公共卫生带来了重大挑战。瞬时受体电位香草酸亚型1（TRPV1）级联反应的激活在脂质代谢和能量摄入中起关键作用。TRPV1在中枢神经系统和外周器官中表达，参与激素分泌、食欲和线粒体功能的调节，被认为是预防肥胖的关键靶点之一。目前的肥胖治疗方法疗效有限，且伴有许多副作用。靶向TRPV1是一种潜在有效的肥胖管理方法。在这项工作中，通过结合TRPV1在神经内分泌调节中作用的最新机制，我们希望提供新的方法来阻止甚至逆转肥胖的发展。
