普通狨猴（Callithrix jacchus）上下消化道联合内镜活检用于评估胃肠道疾病的可行性。

Feasibility of combined upper and lower gastrointestinal endoscopic biopsy in the common marmoset (Callithrix jacchus) to evaluate gastrointestinal diseases.

作者信息

Heilmann Romy M, McIntosh Jenny, Acke Els, Reitemeier Susanne, Pfannkuche Helga, Erdmann Sabrina, Roedler Frauke S, Einspanier Almuth

机构信息

Department for Small Animals, Veterinary Teaching Hospital, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

Institute of Physiological Chemistry, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

出版信息

J Med Primatol. 2022 Jun;51(3):172-178. doi: 10.1111/jmp.12580. Epub 2022 Mar 23.

DOI:10.1111/jmp.12580

PMID:35322434

Abstract

BACKGROUND

Chronic gastroenteropathies, including gluten sensitivity and marmoset wasting syndrome, frequently occur in captive colonies of common marmosets (Callithrix jacchus). Early identification and diagnosis of affected animals are desirable. Endoscopic examination of the colon in marmosets is described, but the small intestine can harbor significant mucosal lesions not representing those in the colon. Evaluating the small intestine currently requires invasive surgical biopsies due to the small patient size, carrying a risk of severe complications.

METHODS

Endoscopic intubation and multisite biopsy of the duodenum/proximal jejunum are demonstrated in 10 marmosets under general anesthesia.

RESULTS

Esophagogastroduodenoscopy with colonoscopy efficiently aid in examining the gastrointestinal tract and obtaining an antemortem histologic diagnosis in marmosets with chronic gastrointestinal signs.

CONCLUSIONS

This minimally invasive technique is feasible in marmosets. Future investigations into the pathogenesis of chronic gastroenteropathies will benefit from these data, leading to improved animal welfare and better individual and colony health management.

摘要

背景

慢性胃肠疾病，包括麸质敏感性和狨猴消瘦综合征，在普通狨猴（Callithrix jacchus）的圈养群体中经常出现。对患病动物进行早期识别和诊断很有必要。已有文献描述了对狨猴结肠的内镜检查，但小肠可能存在与结肠不同的显著黏膜病变。由于狨猴体型小，目前评估小肠需要进行侵入性手术活检，存在严重并发症的风险。