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生物医学研究环境中影响圈养普通狨猴福利的环境与健康因素综述

Review of Environmental and Health Factors Impacting Captive Common Marmoset Welfare in the Biomedical Research Setting.

作者信息

Burns Monika

机构信息

Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

出版信息

Vet Sci. 2023 Sep 12;10(9):568. doi: 10.3390/vetsci10090568.

DOI:10.3390/vetsci10090568
PMID:37756090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10535419/
Abstract

As a small-bodied neotropical nonhuman primate species, common marmosets have unique requirements for adequate husbandry and veterinary care to ensure proper maintenance and to promote good animal welfare in a biomedical research setting. Environmental conditions, as well as medical and research-related manipulations, can impact marmoset welfare. Research focus areas, including basic neuroscience, transgenics, and aging, involve additional implications for marmoset welfare. This manuscript provides a comprehensive review of factors that should be considered and mitigated as needed by clinical and research staff working with marmosets in biomedical research facilities to optimize the welfare of captive marmosets.

摘要

作为一种体型较小的新热带非人类灵长类动物,普通狨猴对适当的饲养管理和兽医护理有独特的要求,以确保在生物医学研究环境中得到妥善照料并促进良好的动物福利。环境条件以及与医学和研究相关的操作都会影响狨猴的福利。包括基础神经科学、转基因和衰老等在内的研究重点领域,对狨猴福利还有其他影响。本手稿全面综述了生物医学研究设施中与狨猴打交道的临床和研究人员应考虑并根据需要减轻的因素,以优化圈养狨猴的福利。

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本文引用的文献

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Development and validation of a cynomolgus macaque grimace scale for acute pain assessment.食蟹猴急性疼痛评估 grimace 量表的开发与验证
Sci Rep. 2023 Feb 24;13(1):3209. doi: 10.1038/s41598-023-30380-x.
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Acclimatizing and training freely viewing marmosets for behavioral and electrophysiological experiments in oculomotor tasks.使(灵长目动物)适应环境并进行自由训练,以用于眼球运动任务中的行为和电生理实验。
Physiol Rep. 2023 Feb;11(3):e15594. doi: 10.14814/phy2.15594.
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The common marmoset in biomedical research: experimental disease models and veterinary management.在生物医学研究中的普通狨猴:实验疾病模型和兽医管理。
Exp Anim. 2023 May 17;72(2):140-150. doi: 10.1538/expanim.22-0107. Epub 2022 Nov 25.
4
Performance of Marmoset Monkeys as Embryo Donors Is Reflected by Different Stress-Related Parameters.狨猴作为胚胎供体的表现可通过不同的应激相关参数反映出来。
Animals (Basel). 2022 Sep 14;12(18):2414. doi: 10.3390/ani12182414.
5
Harmonisation of welfare indicators for macaques and marmosets used or bred for research.用于研究或繁殖的猕猴和狨猴福利指标的协调统一。
F1000Res. 2022 Mar 3;11:272. doi: 10.12688/f1000research.109380.3. eCollection 2022.
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Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter.携带人 EF1α 启动子驱动的突变淀粉样前体蛋白转基因的非人类灵长类动物模型的多模态分析。
Neurosci Res. 2022 Dec;185:49-61. doi: 10.1016/j.neures.2022.08.008. Epub 2022 Sep 6.
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Individual variations and effects of birth facilities on the fecal microbiome of laboratory-bred marmosets (Callithrix jacchus) assessed by a longitudinal study.通过一项纵向研究评估实验室饲养的绒猴(Callithrix jacchus)粪便微生物组的个体差异和出生设施的影响。
PLoS One. 2022 Aug 30;17(8):e0273702. doi: 10.1371/journal.pone.0273702. eCollection 2022.
8
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Toxicol Pathol. 2022 Jul;50(5):628-637. doi: 10.1177/01926233221095449. Epub 2022 May 10.
9
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Nat Methods. 2022 Apr;19(4):496-504. doi: 10.1038/s41592-022-01443-0. Epub 2022 Apr 12.
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Sci Rep. 2022 Mar 28;12(1):5277. doi: 10.1038/s41598-022-09268-9.