Sedlarik K M, Mönch C, Haenselt V, Riedel E, Dürschmied H
Res Exp Med (Berl). 1986;186(4):271-84. doi: 10.1007/BF01852304.
Pulmonary thromboembolism is one of the most frequent causes of death in our days. Notwithstanding the great efforts made in clinical and experimental medicine there has been no success as yet in filling the existing gaps in the understanding of pathophysiology of this disease. The blood electrically activated in vitro by direct current reacts like an endogenic thrombogenic substance. On the condition that such a substance is injected into the inferior vena cava, the clot is introduced into the pulmonary circulation and gives rise to pulmonary thromboembolism of a varying degree, each depending on the electrically activated blood injected. In the animal experiment it has thus become feasible, under standardized and reproducible conditions, to produce severe thromboembolism or chronic microembolism with subsequent hypertrophy of the right ventricle. The object of this contribution is a demonstration of a new, easy, and effective method for the induction of pulmonary embolism, which can be treated by thrombolysis.
肺血栓栓塞是当今最常见的死亡原因之一。尽管临床和实验医学付出了巨大努力，但在填补对该疾病病理生理学理解方面的现有空白方面尚未取得成功。体外经直流电激活的血液表现得像一种内源性血栓形成物质。如果将这种物质注入下腔静脉，凝块就会进入肺循环，引发不同程度的肺血栓栓塞，其程度取决于注入的经电激活的血液量。在动物实验中，因此在标准化和可重复的条件下，制造严重血栓栓塞或慢性微栓塞并随后导致右心室肥大已成为可行的。本文的目的是展示一种诱导肺栓塞的新的、简便且有效的方法，这种方法可以通过溶栓治疗。
