Yang Xueyi, Qu Kaixing, Liu Jianyong, Qi Xinglei, Li Fuqiang, Zhang Jicai, Huang Bizhi, Lei Chuzhao
Life Science College, Luoyang Normal University, Luoyang, China.
Academy of Science and Technology, Chuxiong Normal University, Chuxiong, China.
Anim Biotechnol. 2023 Nov;34(6):1876-1882. doi: 10.1080/10495398.2022.2053697. Epub 2022 Mar 24.
Type I keratin 9 encoded by the gene serves an important special function either in the mature palmar and plantar skin tissue. The changes in skin conditions and thickening of the outer layer of the skin may be affected by environmental variables. A missense mutation rs209302038 (NC_037346.1: g.41782870 G > A) was detected in , which changing the isoleucine into valine. This study aimed to identify the frequency of allele in this locus in Chinese indigenous cattle, and analyze the connection with heat stress. Our results indicated that the frequency of allele A gradually decreases from south to north, while the frequency of G allele showed the opposite pattern. Further analysis of the association of the different genotypes with three climate factors, which showed that the genotypes (GG, GA, AA) were significantly related to climatic conditions ( < 0.01). Therefore, we speculated that the mutation of the rs209302038 in Chinese indigenous cattle might be a genetic marker to detect heat stress.
由该基因编码的I型角蛋白9在成熟的手掌和足底皮肤组织中发挥着重要的特殊功能。皮肤状况的变化和皮肤外层的增厚可能受环境变量影响。在该基因中检测到一个错义突变rs209302038（NC_037346.1: g.41782870 G > A），该突变将异亮氨酸变为缬氨酸。本研究旨在确定中国本土牛该位点等位基因的频率，并分析其与热应激的关系。我们的结果表明，等位基因A的频率从南到北逐渐降低，而G等位基因的频率呈现相反的模式。进一步分析不同基因型与三种气候因素的关联，结果显示基因型（GG、GA、AA）与气候条件显著相关（ < 0.01）。因此，我们推测中国本土牛中rs209302038的突变可能是检测热应激的一个遗传标记。
