Mazziotta Francesco, Buda Gabriele, Del Giudice Maria Livia, Orciuolo Enrico, Benedetti Edoardo, Masini Matilde, De Tata Vincenzo, Galimberti Sara, Petrini Mario
Hematology Division, Pisa University Hospital, 56126 Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, Pisa University Hospital, 56126 Pisa, Italy.
Hematol Rep. 2022 Mar 2;14(1):19-23. doi: 10.3390/hematolrep14010004.
Amyloidosis is a rare disease that is often seen in conjunction with multiple myeloma (MM). Its damage varies depending on the anatomical site affected; however, it is believed that many cases of amyloidosis are misrecognized due to the fact that its signs and symptoms are nonspecific. Joint amyloidosis, in particular, may be confused with degenerative or autoimmune diseases. When it is associated with MM, it can significantly precede the diagnosis of the latter. We describe a case report of a woman of Nigerian heritage diagnosed with MM with widespread joint manifestations compatible with a diagnosis of amyloidosis, which had preceded the diagnosis of MM and benefited from MM treatment. Faced with the suspicion of amyloidosis, if confirmed, this can be used to anticipate the diagnosis of MM, and at a more advanced stage, it can benefit from the treatment of the MM.
淀粉样变性是一种罕见疾病，常与多发性骨髓瘤（MM）同时出现。其损害因受影响的解剖部位而异；然而，由于淀粉样变性的体征和症状不具特异性，许多病例被误诊。特别是关节淀粉样变性，可能会与退行性或自身免疫性疾病相混淆。当它与MM相关时，可能在MM诊断之前就已出现。我们报告一例病例，一名有尼日利亚血统的女性被诊断为MM，伴有广泛的关节表现，符合淀粉样变性诊断，该疾病先于MM诊断出现，并从MM治疗中获益。面对淀粉样变性的怀疑，如果得到证实，可用于预测MM的诊断，在更晚期阶段，可从MM治疗中获益。
