Department of Aerospace Systems Engineering, School of Astronautics, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China.
Biosensors (Basel). 2022 Mar 2;12(3):156. doi: 10.3390/bios12030156.
The magnetic manipulation of droplets is one of the emerging magnetofluidic technologies that integrate multiple disciplines, such as electromagnetics, fluid mechanics and so on. The directly driven droplets are mainly composed of ferrofluid or liquid metal. This kind of magnetically induced droplet manipulation provides a remote, wireless and programmable approach beneficial for research and engineering applications, such as drug synthesis, biochemistry, sample preparation in life sciences, biomedicine, tissue engineering, etc. Based on the significant growth in the study of magneto droplet handling achieved over the past decades, further and more profound explorations in this field gained impetus, raising concentrations on the construction of a comprehensive working mechanism and the commercialization of this technology. Current challenges faced are not limited to the design and fabrication of the magnetic field, the material, the acquisition of precise and stable droplet performance, other constraints in processing speed and so on. The rotational devices or systems could give rise to additional issues on bulky appearance, high cost, low reliability, etc. Various magnetically introduced droplet behaviors, such as deformation, displacement, rotation, levitation, splitting and fusion, are mainly introduced in this work, involving the basic theory, functions and working principles.
液滴的磁操控是一种新兴的磁流控技术,集成了电磁学、流体力学等多个学科。直接驱动的液滴主要由铁磁流体或液态金属组成。这种磁诱导的液滴操控提供了一种远程、无线和可编程的方法,有利于药物合成、生物化学、生命科学中的样品制备、生物医学、组织工程等研究和工程应用。基于过去几十年在磁控液滴处理研究方面取得的显著进展,该领域进一步得到了更深入和更广泛的探索,集中于构建全面的工作机制和该技术的商业化。目前面临的挑战不仅限于磁场的设计和制造、材料、精确和稳定的液滴性能的获取,还有处理速度等方面的其他限制。旋转装置或系统可能会带来体积庞大、成本高、可靠性低等额外问题。本文主要介绍了各种磁控引入的液滴行为,如变形、位移、旋转、悬浮、分裂和融合,涉及基本理论、功能和工作原理。