Sattari Amirmohammad, Hanafizadeh Pedram, Hoorfar Mina
School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran; School of Engineering, University of British Columbia, Kelowna, BC, Canada.
School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Adv Colloid Interface Sci. 2020 Aug;282:102208. doi: 10.1016/j.cis.2020.102208. Epub 2020 Jul 18.
Microfluidic technologies have a unique ability to control more precisely and effectively on two-phase flow systems in comparison with macro systems. Controlling the size of the droplets and bubbles has led to an ever-increasing expansion of this technology in two-phase systems. Liquid-liquid and gas-liquid two-phase flows because of their numerous applications in different branches such as reactions, synthesis, emulsions, cosmetic, food, drug delivery, etc. have been the most critical two-phase flows in microfluidic systems. This review highlights recent progress in two-phase flows in microfluidic devices. The fundamentals of two-phase flows, including some essential dimensionless numbers, governing equations, and some most well-known numerical methods are firstly introduced, followed by a review of standard methods for producing segmented flows such as emulsions in microfluidic systems. Then various encapsulated structures, a common two-phase flow structure in microfluidic devices, and different methods of their production are reviewed. Finally, applications of two-phase microfluidic flows in drug-delivery, biotechnology, mixing, and microreactors are briefly discussed.
与宏观系统相比，微流控技术具有独特的能力，能够更精确、有效地控制两相流系统。对液滴和气泡尺寸的控制使得该技术在两相系统中的应用不断扩大。液-液和气-液两相流因其在反应、合成、乳液、化妆品、食品、药物递送等不同领域的众多应用，一直是微流控系统中最关键的两相流。本综述重点介绍了微流控装置中两相流的最新进展。首先介绍了两相流的基本原理，包括一些重要的无量纲数、控制方程和一些最著名的数值方法，随后回顾了在微流控系统中产生分段流（如乳液）的标准方法。然后综述了各种封装结构，这是微流控装置中常见的两相流结构及其不同的生产方法。最后简要讨论了两相微流控流在药物递送、生物技术、混合和微反应器中的应用。
