Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
Clinic for Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, Ulm, Germany.
Stress. 2021 Jul;24(4):404-412. doi: 10.1080/10253890.2020.1869935. Epub 2021 Jan 28.
The wear and tear of the body caused by stressful events is subject of extensive research and can be measured by the allostatic load index (ALI). The aim of this cross-sectional study was to replicate an ALI-5 score in a population sample in the USA and to compare these findings with the original ALI-10 score. Data from the Midlife in the United States Study (MIDUS) assessed between 2004 and 2016 were used to calculate different ALI risk scores with 5 and 10 variables, respectively. Examinations included anthropometric data, heart rate variability (HRV), and blood and urine samples. Questionnaires assessed information on perceived stress and medical history. Logistic regression models estimated odds ratios (OR) with corresponding 95% confidence intervals (CIs) for the association between ALI indices and perceived stress, controlling for various confounders. Subgroup analysis explored the difference in gender and in three age clusters. Data of 1421 participants (43% male, 50.4 ± 9.3 years) were included in the analysis. Adjusted logistic regression models showed an odds ratio of 1.37 ± 0.19 (CI 1.05, 1.80; =.022) for the association of ALI-5 with perceived stress. This association was stronger in females (OR = 1.62 ± 0.28, CI 1.15, 2.28; = .006) and did not significantly differ between age clusters. Results for the original ALI-10 score did not reach significance. The streamlined ALI-5 score seems to be a reliable risk score and is strongly associated with perceived stress in life. Longitudinal studies should further elaborate this association in different samples.: Stress from different sources can lead to serious diseases. A short composite index comprising of five medical variables is highly associated with perceived stress. This index is able to serve as an early indicator to detect people who are at risk to develop stress-related diseases.
身体因应激事件造成的损耗是广泛研究的课题，可通过应激反应的累积负担（allostatic load index，ALI）来衡量。本横断面研究旨在复制美国人群样本中的 ALI-5 评分，并与原始的 ALI-10 评分进行比较。研究使用了 2004 年至 2016 年美国中年研究（Midlife in the United States Study，MIDUS）的数据来计算具有 5 个和 10 个变量的不同 ALI 风险评分。检查包括人体测量数据、心率变异性（heart rate variability，HRV）以及血液和尿液样本。问卷调查评估了感知压力和病史的信息。逻辑回归模型估计了 ALI 指数与感知压力之间关联的优势比（odds ratio，OR）及其 95%置信区间（confidence interval，CI），并控制了各种混杂因素。亚组分析探索了性别和三个年龄组之间的差异。共纳入 1421 名参与者（43%为男性，50.4 ± 9.3 岁）进行分析。调整后的逻辑回归模型显示，ALI-5 与感知压力相关的比值比（odds ratio，OR）为 1.37 ± 0.19（95%CI：1.05，1.80； = 0.022）。在女性中，这种关联更强（OR = 1.62 ± 0.28，95%CI：1.15，2.28； = 0.006），并且在不同年龄组之间无显著差异。原始的 ALI-10 评分的结果没有达到显著性。简化后的 ALI-5 评分似乎是一种可靠的风险评分，与生活中的感知压力密切相关。纵向研究应在不同样本中进一步阐述这种关联。
压力源会导致严重疾病。由五个医学变量组成的简短综合指数与感知压力高度相关。该指数可以作为一种早期指标，用于检测有患应激相关疾病风险的人群。
