Boullaud Luc, Blasco Hélène, Trinh Thuy-Trân, Bakhos David
ENT Department and Cervico-Facial Surgery, University Center Hospital of Tours, 2 Boulevard Tonnellé, 37044 Tours, France.
INSERM U1253, iBrain, University of Tours, 10 Boulevard Tonnellé, 37000 Tours, France.
Metabolites. 2022 Feb 26;12(3):214. doi: 10.3390/metabo12030214.
Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin proteins, mitochondrial genes, etc.). For cytomegalovirus infection or auditory neuropathies, mechanisms are also well known and well researched. Although the etiologies of sensorineural hearing loss may be evident for some patients, the damaged sites and pathological mechanisms remain unclear for patients with progressive post-lingual hearing loss. Metabolomics is an emerging technique in which all metabolites present in a sample at a given time are analyzed, reflecting a physiological state. The objective of this study was to review the literature on the use of metabolomics in hearing loss. The findings of this review suggest that metabolomic studies may help to develop objective tests for diagnosis and personalized treatment.
感音神经性听力损失是最常见的感觉缺陷。感音神经性听力损失的病因已被描述，可分为先天性或后天性。对于先天性非综合征性听力损失，已发现与耳蜗损伤部位相关的突变（例如，连接蛋白、线粒体基因等）。对于巨细胞病毒感染或听觉神经病，其机制也已为人熟知且研究充分。尽管某些患者的感音神经性听力损失病因可能很明显，但对于进行性语后听力损失患者，受损部位和病理机制仍不清楚。代谢组学是一种新兴技术，可分析给定时间样本中存在的所有代谢物，反映生理状态。本研究的目的是综述关于代谢组学在听力损失中应用的文献。该综述的结果表明，代谢组学研究可能有助于开发用于诊断和个性化治疗的客观测试。
