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长新冠综合征与肺部:它将持续多久?

Long COVID syndrome and the lung: how long will it last?

机构信息

From the Department of Medicine, Tallaght University Hospital & Trinity College Dublin, Dublin, D24 NR0A, Ireland.

From the Department of Medicine, Tallaght University Hospital & Trinity College Dublin, Dublin, D24 NR0A , Ireland.

出版信息

QJM. 2022 Jun 7;115(6):349-350. doi: 10.1093/qjmed/hcac070.

DOI:10.1093/qjmed/hcac070
PMID:35323978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9383566/
Abstract

The prevalence and duration of the long-term respiratory complications of COVID-19 infection remains to be elucidated. This short commentary reports on recently published studies in patients post-acute COVID-19 infection in terms of symptom prevalence, physiological and radiological sequela and where only symptoms are present despite investigation. Pulmonary function testing, 6-min walk tests, computed tomography chest and more advanced imaging modalities have been incorporated to reveal the underlying pathophysiology that cause such disabling symptoms in patient with post-acute COVID-9 syndrome (PACS). PACS has a serious impact on people's ability to return to work, affecting the physical, mental, social sphere and with significant healthcare and general economic consequences for them, their families and society.

摘要

COVID-19 感染的长期呼吸系统并发症的流行率和持续时间仍有待阐明。本短评报告了最近发表的关于急性 COVID-19 感染后患者的研究,涉及症状流行率、生理和放射学后遗症,以及尽管进行了调查但仅存在症状的情况。肺功能测试、6 分钟步行测试、胸部计算机断层扫描和更先进的成像方式已被纳入,以揭示导致急性 COVID-9 后综合征(PACS)患者出现这些使活动受限的症状的潜在病理生理学。PACS 严重影响人们重返工作岗位的能力,影响他们的身体、心理、社会领域,并对他们、他们的家庭和社会造成重大的医疗保健和总体经济后果。

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本文引用的文献

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Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19.COVID-19 后 273618 例幸存者的 6 个月回顾性队列研究:长新冠症状的发生率、共病和演变。
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1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study.COVID-19 住院幸存者 1 年结局:一项纵向队列研究。
Lancet. 2021 Aug 28;398(10302):747-758. doi: 10.1016/S0140-6736(21)01755-4.
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COVID-19 and the effects on pulmonary function following infection: A retrospective analysis.新型冠状病毒肺炎及其感染后对肺功能的影响:一项回顾性分析。
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Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol.新型冠状病毒肺炎后从英国医院出院的成年人的长期新冠症状:一项采用国际严重急性呼吸道感染和新发传染病临床协作组(ISARIC)世界卫生组织临床特征协议的前瞻性多中心队列研究。
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Cardiopulmonary exercise capacity and limitations 3 months after COVID-19 hospitalisation.新冠肺炎住院 3 个月后的心肺运动能力及其局限性。
Eur Respir J. 2021 Aug 26;58(2). doi: 10.1183/13993003.00996-2021. Print 2021 Aug.
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Post-acute COVID-19 syndrome.新冠病毒感染后长期综合征。
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US health agency will invest $1 billion to investigate 'long COVID'.美国卫生机构将投入10亿美元调查“长新冠”。
Nature. 2021 Mar;591(7850):356. doi: 10.1038/d41586-021-00586-y.
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Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life.COVID-19 对肺功能、功能能力和生活质量的中期影响。
Eur Respir J. 2021 Sep 16;58(3). doi: 10.1183/13993003.04015-2020. Print 2021 Sep.
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Six-month Follow-up Chest CT Findings after Severe COVID-19 Pneumonia.重症 COVID-19 肺炎患者 6 个月随访的胸部 CT 结果。
Radiology. 2021 Apr;299(1):E177-E186. doi: 10.1148/radiol.2021203153. Epub 2021 Jan 26.
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Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis.COVID-19 感染后患者的呼吸功能:系统评价和荟萃分析。
Pulmonology. 2021 Jul-Aug;27(4):328-337. doi: 10.1016/j.pulmoe.2020.10.013. Epub 2020 Nov 25.