Mayumi H, Himeno K, Tanaka K, Tokuda N, Fan J L, Nomoto K
Transplantation. 1986 Oct;42(4):417-22.
Graft-versus-host reaction (GVH) after allogeneic spleen cell transplantation was completely suppressed in an H-2-matched murine combination (AKR/J Sea [H-2k]----lethally irradiated C3H/He Slc [H-2k]) by pretreatment of the donors with recipient spleen cell antigen plus cyclophosphamide (CP). Irradiated recipients receiving cells became chimeric. In contrast to the H-2 matched combination, lethal GVH reaction could not be prevented in an H-2-mismatched fully allogeneic combination (C57BL/6 Cr Slc [H-2b]----lethally irradiated C3H/He Slc [H-2k]) by pretreatment of the donors. The results suggest that the effectors responsible for the GVH reaction were abrogated by pretreatment of the donors with allogeneic recipient spleen cells plus CP in the H-2-matched combination, but donor pretreatment failed to abrogate GVH reaction in the H-2-mismatched combination.
在同基因脾细胞移植后发生的移植物抗宿主反应（GVH），在一个H-2匹配的小鼠组合（AKR/J Sea [H-2k]→经致死剂量照射的C3H/He Slc [H-2k]）中，通过用受体脾细胞抗原加环磷酰胺（CP）预处理供体而被完全抑制。接受细胞的受照射受体变成了嵌合体。与H-2匹配组合相反，在一个H-2不匹配的完全异基因组合（C57BL/6 Cr Slc [H-2b]→经致死剂量照射的C3H/He Slc [H-2k]）中，供体的预处理不能预防致死性GVH反应。结果表明，在H-2匹配组合中，用异基因受体脾细胞加CP预处理供体可消除负责GVH反应的效应细胞，但在H-2不匹配组合中，供体预处理未能消除GVH反应。
