Guidi Patrizia, Bernardeschi Margherita, Scarcelli Vittoria, Lucchesi Paolo, Palumbo Mara, Corsi Ilaria, Frenzilli Giada
Section of Applied Biology and Genetics and INSTM Local Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Department of Physical, Earth and Environmental Science and INSTM Local Unit, University of Siena, 53100 Siena, Italy.
Toxics. 2022 Feb 26;10(3):111. doi: 10.3390/toxics10030111.
The contamination of marine water bodies with petroleum hydrocarbons represents a threat to ecosystems and human health. In addition to the surface slick of crude oil, the water-soluble fraction of petroleum is responsible for the induction of severe toxic effects at different cellular and molecular levels. Some petroleum-derived hydrocarbons are classified as carcinogenic and mutagenic contaminants; therefore, the oil spill into the marine environment can have long term consequences to the biota. Therefore, new tools able to remediate crude oil water accommodation fraction pollution in marine water are highly recommended. Nanomaterials were recently proposed in environmental remediation processes. In the present in vivo study, the efficacy of pure anatase titanium nanoparticles (n-TiO) was tested on exposed to the accommodated fraction of crude oil. It was found that n-TiO nano-powders themselves were harmless in terms of DNA primary damage, and the capability of pure anatase n-TiO to lower the levels of DNA damage induced by a mixture of genotoxic pollutant was revealed. These preliminary results on a laboratory scale are the prerequisite for deepening this new technology for the abatement of the cellular effects related with oil spill pollutants released in marine environments.
海洋水体被石油碳氢化合物污染对生态系统和人类健康构成威胁。除了原油的表面浮油外,石油的水溶性部分会在不同细胞和分子水平上引发严重的毒性作用。一些石油衍生的碳氢化合物被归类为致癌和致突变污染物;因此,石油泄漏到海洋环境中会对生物群产生长期影响。因此,强烈推荐能够修复海水中原油水相组分污染的新工具。纳米材料最近被应用于环境修复过程。在目前的体内研究中,测试了纯锐钛矿型钛纳米颗粒(n-TiO)对暴露于原油水相组分的效果。结果发现,n-TiO纳米粉末本身在DNA初级损伤方面是无害的,并且揭示了纯锐钛矿型n-TiO降低遗传毒性污染物混合物诱导的DNA损伤水平的能力。这些实验室规模的初步结果是深化这项新技术以减轻与海洋环境中释放的溢油污染物相关的细胞效应的前提条件。