护士邻苯二甲酸盐暴露与腹部肥胖风险
Risk of Abdominal Obesity Associated with Phthalate Exposure of Nurses.
作者信息
Kolena Branislav, Hlisníková Henrieta, Kečkéšová Ľubica, Šidlovská Miroslava, Trnovec Tomáš, Petrovičová Ida
机构信息
Department of Zoology and Anthropology, Constantine the Philosopher University in Nitra, 94974 Nitra, Slovakia.
Department of Environmental Medicine, Slovak Medical University, 83303 Bratislava, Slovakia.
出版信息
Toxics. 2022 Mar 18;10(3):143. doi: 10.3390/toxics10030143.
Background: Occupational health hazards associated with phthalate exposure among nurses are still not well understood. Methods: We used high-performance liquid chromatography and tandem mass spectrometry to analyze phthalates. Anthropometric measurements and questionnaires were conducted. Results: We observed associations between mono-benzyl phthalate (MBzP) and body mass index (BMI), hip circumference (HC), waist circumference (WC), waist to height ratio (WHtR), and fat mass index (FMI), visceral fat content, BMI risk and hip index risk (HIrisk), adjusted to consumer behavior and consumer practices (r = 0.36−0.61; p ≤ 0.046). In the same model, we detected an association between mono-n-butyl phthalate (MnBP) and waist to hip ratio (WHR; r = 0.36; p = 0.046), mono-carboxy-isononyl phthalate (cx-MiNP) and BMI (r = 0.37; p = 0.043), HC (r = 0.4; p = 0.026) and WHtR (r = 0.38; p = 0.037), between mono-oxo-isononyl phthalate oxo (MiNP) and HC (r = 0.36; p = 0.045), mono-2-ethylhexyl phthalate (MEHP), mono(2-ethyl-5-oxohexyl) phthalate (oxo-MEHP) and HIrisk (r = 0.38−0.41; p ≤ 0.036), between oxo-MEHP and Anthropometric Risk Index (ARI risk; r = 0.4; p = 0.028). We detected a relationship between BMI and MBzP (β = 0.655; p < 0.001) and mono-2-ethylhexyl phthalate (MEHP; β = −0.365; p = 0.003), between hip circumference and MBzP (β = 0.486; p < 0.001), MEHP (β = −0.402; p = 0.001), and sum of secondary metabolites of diisononyl phthalate (∑DiNP; β = 0.307; p = 0.016). We observed a relationship between fat content and MBzP (β = 0.302; p = 0.033), OH-MnBP (β = −0.736; p = 0.006) and MiBP (β = 0.547; p = 0.046), visceral fat content and MBzP (β = 0.307; p = 0.030), HI-risk and MBzP (β = 0.444; p = 0.001), ARI-risk and sum of di-n-butyl phthalate metabolites (∑DnBP; β = 0.337; p = 0.018). We observed an association between the use of protective equipment with cx-MiNP. Conclusions: Occupational exposure to phthalates may induce abdominal obesity and result in obesity-related metabolic disorders.
背景
护士接触邻苯二甲酸盐所带来的职业健康危害仍未得到充分了解。方法：我们使用高效液相色谱和串联质谱法分析邻苯二甲酸盐。进行了人体测量和问卷调查。结果：我们观察到，在调整了消费行为和消费习惯后，邻苯二甲酸单苄酯（MBzP）与体重指数（BMI）、臀围（HC）、腰围（WC）、腰高比（WHtR）和脂肪量指数（FMI）、内脏脂肪含量、BMI风险和臀围指数风险（HIrisk）之间存在关联（r = 0.36−0.61；p≤0.046）。在同一模型中，我们检测到邻苯二甲酸单丁酯（MnBP）与腰臀比（WHR；r = 0.36；p = 0.046）、单羧基异壬基邻苯二甲酸酯（cx-MiNP）与BMI（r = 0.37；p = 0.043）、HC（r = 0.4；p = 0.026）和WHtR（r = 0.38；p = 0.037）之间存在关联，单氧代异壬基邻苯二甲酸酯（oxo-MiNP）与HC（r = 0.36；p = 0.045）、邻苯二甲酸单（2-乙基己基）酯（MEHP）、单（2-乙基-5-氧代己基）邻苯二甲酸酯（oxo-MEHP）与HIrisk（r = 0.38−0.41；p≤0.036）、oxo-MEHP与人体测量风险指数（ARI风险；r = 0.4；p = 0.028）之间存在关联。我们检测到BMI与MBzP（β = 0.655；p < 0.001）和邻苯二甲酸单（2-乙基己基）酯（MEHP；β = -0.365；p = 0.003）之间、臀围与MBzP（β = 0.486；p < 0.001）、MEHP（β = -0.402；p = 0.001）以及邻苯二甲酸二异壬酯次级代谢产物总和（∑DiNP；β = 0.307；p = 0.016）之间存在关系。我们观察到脂肪含量与MBzP（β = 0.302；p = 0.033）、羟基邻苯二甲酸单丁酯（OH-MnBP；β = -0.736；p = 0.006）和邻苯二甲酸单异丁酯（MiBP；β = 0.547；p = 0.046）之间、内脏脂肪含量与MBzP（β = 0.307；p = 0.030）、HI风险与MBzP（β = 0.444；p = 0.001）、ARI风险与邻苯二甲酸二丁酯代谢产物总和（∑DnBP；β = 0.337；p = 0.0
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