Han Su-Jin, Lee Seung-Hwan
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Obes Metab Syndr. 2021 Jun 30;30(2):93-103. doi: 10.7570/jomes21004.
Overweight and obesity, which have rapidly increased around the world in recent years, are significant health problems. They can lead to various morbidities, including cardiovascular diseases, cerebrovascular diseases, type 2 diabetes, some types of cancer, and even death. Obesity is caused by an energy imbalance due to excessive calorie intake and insufficient energy consumption, and genetic factors and individual behavioral problems are also known to be major contributing factors. However, these are insufficient to explain the surge in obesity that has occurred in recent decades. Recent studies have suggested that environmental factors arising from the process of socioeconomic development and modernization contribute to this phenomenon. These environmental factors include light pollution due to artificial lighting, air pollution, endocrine-disrupting chemicals, and reduced exposure to green spaces due to urbanization of residential areas. In this manuscript, the findings and mechanisms of these novel risk factors causing overweight and obesity are reviewed.
超重和肥胖近年来在全球范围内迅速增加,是重大的健康问题。它们可导致各种疾病,包括心血管疾病、脑血管疾病、2型糖尿病、某些类型的癌症,甚至死亡。肥胖是由热量摄入过多和能量消耗不足导致的能量失衡引起的,遗传因素和个人行为问题也是主要的促成因素。然而,这些不足以解释近几十年来肥胖率的激增。最近的研究表明,社会经济发展和现代化进程中产生的环境因素促成了这一现象。这些环境因素包括人工照明导致的光污染、空气污染、内分泌干扰化学物质以及居民区城市化导致的绿地接触减少。在本手稿中,将对这些导致超重和肥胖的新风险因素的研究结果和机制进行综述。