Coenen Marie-Charlotte, Gille Linde, Eppe Justine, Casalta Hélène, Bayrou Calixte, Dubreucq Pierre, Frisée Vincent, Moula Nassim, Evrard Julien, Martinelle Ludovic, Sartelet Arnaud, Bossaert Philippe, Djebala Salem
Clinical Department of Production Animals, University of Liège, Quartier Vallée 2, Avenue de Cureghem 7A-7D, 4000 Liège, Belgium.
Department of Animal Production, University of Liege, Quartier Vallée 2, Avenue de Cureghem 6, 4000 Liège, Belgium.
Vet Sci. 2022 Mar 14;9(3):134. doi: 10.3390/vetsci9030134.
This study aimed to describe the inflammation, hydro-electrolyte and acid-base imbalances caused by generalised peritonitis (GP) and parietal fibrinous peritonitis (PFP) after caesarean section. After clinical examination, blood was sampled from 11 cows with PFP, 30 with GP and 14 healthy cows. Serum and plasma refractometry and glutaraldehyde tests were used to evaluate the inflammation level, while hydro-electrolytes and acid-base parameters were assessed using an EPOC® device. In addition to clinical signs of dehydration (>10%), blood analysis showed a high fibrinogen concentration (PFP: 8.64 ± 8.82 g/L; GP: 7.83 ± 2.45 g/L) and fast glutaraldehyde coagulation (<3 min) indicative of severe inflammation in both diseases compared to the control group (p < 0.05). Moreover, a severe decrease in electrolytes concentration (Na+: 126.93 ± 5.79 mmol/L; K+: 3.7 ± 1.3 mmol/L; Ca++: 0.89 ± 0.12 mmol/L; Cl−: 82.38 ± 6.45 mmol/L) and a significant increase in bicarbonate (30.87 ± 8.16 mmol/L), base excess (5.71 ± 7.42 mmol/l), L-lactate (8.1 ± 4.85 mmol/L) and creatinine (3.53 ± 2.30 mg/dL) were observed in cows with GP compared to the control group (p < 0.05). In contrast, few major perturbations were noticed in PFP, where only K+ (3.64 ± 0.25 mmol/L) and Ca++ (1.06 ± 0.09 mmol/L) were significantly modified (p < 0.05). In conclusion, a high dehydration and severe inflammation are induced by PFP and GP. Nevertheless, GP causes more electrolytes and acid-base disturbances than PFP.
本研究旨在描述剖宫产术后全身性腹膜炎（GP）和壁层纤维蛋白性腹膜炎（PFP）所引起的炎症、水电解质及酸碱失衡情况。临床检查后，采集了11头患有PFP的奶牛、30头患有GP的奶牛以及14头健康奶牛的血液样本。采用血清和血浆折射测定法及戊二醛试验评估炎症水平，同时使用EPOC®设备评估水电解质和酸碱参数。除了脱水的临床体征（>10%）外，血液分析显示，与对照组相比，两种疾病的纤维蛋白原浓度均较高（PFP：8.64±8.82 g/L；GP：7.83±2.45 g/L），且戊二醛快速凝固（<3分钟），表明存在严重炎症（p<0.05）。此外，与对照组相比，患有GP的奶牛电解质浓度显著降低（Na+：126.93±5.79 mmol/L；K+：3.7±1.3 mmol/L；Ca++：0.89±0.12 mmol/L；Cl−：82.38±6.45 mmol/L），碳酸氢盐（30.87±8.16 mmol/L）、碱剩余（5.71±7.42 mmol/l）、L-乳酸（8.1±4.85 mmol/L）和肌酐（3.53±2.30 mg/dL）显著升高（p<0.05）。相比之下，PFP中仅发现少数主要的紊乱情况，其中只有K+（3.64±0.25 mmol/L）和Ca++（1.06±0.09 mmol/L）有显著变化（p<0.05）。总之，PFP和GP会导致高度脱水和严重炎症。然而，GP比PFP引起更多的电解质和酸碱紊乱。
