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[向动物脑池内注射精神分裂症患者脑脊液后动物脑内的生化及超微结构变化]

[Biochemical and ultrastructural changes in animal brain after intracisternal administration of the cerebrospinal fluid from patients with schizophrenia].

作者信息

Vilkov G A, Trapezontseva R A, Siletskiĭ O Ia, Bardakhch'ian E A, Minoranskaia A P

出版信息

Vopr Med Khim. 1986 Jul-Aug;32(4):91-3.

PMID:3532532
Abstract

After intracisternal administration of liquor from patients with schizophrenia into rabbits and rats content of catecholamines, gangliosides and cerebrosides was decreased, while acid proteinase was activated in brain tissue. At the same time, ultrastructural impairments occurred in nervous cells. These data suggest that cytotoxic antibrain antibodies are present in liquor of schizophrenic patients.

摘要

将精神分裂症患者的脑脊液注入兔和大鼠的脑池后,其脑组织中儿茶酚胺、神经节苷脂和脑苷脂的含量降低,而酸性蛋白酶被激活。与此同时,神经细胞出现超微结构损伤。这些数据表明,精神分裂症患者的脑脊液中存在细胞毒性抗脑抗体。

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Vopr Med Khim. 1986 Jul-Aug;32(4):91-3.
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