Zakaria Ali, Al-Share Bayan, Klapman Jason B, Dam Aamir
Department of Gastroenterology-Advanced Endoscopy, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Department of Hematology and Oncology, Karmanos Cancer Center, Wayne State University, Detroit, MI 48201, USA.
Cancers (Basel). 2022 Mar 8;14(6):1373. doi: 10.3390/cancers14061373.
Pancreatic cancer is the fourth leading cause of cancer-related death and the second gastrointestinal cancer-related death in the United States. Early detection and accurate diagnosis and staging of pancreatic cancer are paramount in guiding treatment plans, as surgical resection can provide the only potential cure for this disease. The overall prognosis of pancreatic cancer is poor even in patients with resectable disease. The 5-year survival after surgical resection is ~10% in node-positive disease compared to ~30% in node-negative disease. The advancement of imaging studies and the multidisciplinary approach involving radiologists, gastroenterologists, advanced endoscopists, medical, radiation, and surgical oncologists have a major impact on the management of pancreatic cancer. Endoscopic ultrasonography is essential in the diagnosis by obtaining tissue (FNA or FNB) and in the loco-regional staging of the disease. The advancement in EUS techniques has made this modality a critical adjunct in the management process of pancreatic cancer. In this review article, we provide an overall description of the role of endoscopic ultrasonography in the diagnosis and staging of pancreatic cancer.
胰腺癌是美国癌症相关死亡的第四大原因，也是胃肠道癌症相关死亡的第二大原因。胰腺癌的早期检测、准确诊断和分期对于指导治疗方案至关重要，因为手术切除是这种疾病唯一可能的治愈方法。即使是可切除疾病的患者，胰腺癌的总体预后也很差。有淋巴结转移疾病患者手术切除后的5年生存率约为10%，而无淋巴结转移疾病患者为约30%。影像学研究的进展以及包括放射科医生、胃肠病学家、高级内镜专家、医学、放射和外科肿瘤学家在内的多学科方法对胰腺癌的管理产生了重大影响。内镜超声检查对于通过获取组织（细针穿刺抽吸或细针穿刺活检）进行诊断以及对疾病进行局部区域分期至关重要。内镜超声技术的进步使这种检查方式成为胰腺癌管理过程中的关键辅助手段。在这篇综述文章中，我们全面描述了内镜超声检查在胰腺癌诊断和分期中的作用。
