Stohs S J, Reinke L A, Hassing J M, Rosenberg H
Drug Metab Dispos. 1979 Jan-Feb;7(1):49-51.
The metabolism of benzo[a]pyrene (BP) by microsomes from hepatic and extrahepatic tissues of female diabetic rats was investigated. Diabetes was produced by the administration of streptozotocin, 60 mg/kg iv, and BP metabolism was studied 7 or 10 days later. BP metabolism was increased in hepatic microsomes by 75% in diabetic animals. Cytochrome P-450 levels were similarly increased. BP mono-oxygenase activity was tripled in intestinal microsomes of diabetic rats, and returned to control values on insulin treatment. The BP mono-oxygenase activity in lung microsomes from diabetic rats decreased by 40%, and was increased to control levels after insulin treatment. No significant changes in BP metabolism were observed in the kidney and adrenal tissues of diabetic animals.
研究了雌性糖尿病大鼠肝组织和肝外组织微粒体对苯并[a]芘（BP）的代谢情况。通过静脉注射链脲佐菌素（60mg/kg）诱导糖尿病，7或10天后研究BP代谢。糖尿病动物肝微粒体中BP代谢增加了75%。细胞色素P-450水平也有类似增加。糖尿病大鼠肠道微粒体中BP单加氧酶活性增加了两倍，胰岛素治疗后恢复到对照值。糖尿病大鼠肺微粒体中BP单加氧酶活性降低了40%，胰岛素治疗后增加到对照水平。糖尿病动物肾脏和肾上腺组织中BP代谢未观察到显著变化。
