Reinke L A, Rosenberg H, Stohs S J
Res Commun Chem Pathol Pharmacol. 1978 Mar;19(3):445-52.
The total metabolism of androstenedione by hepatic microsomes from streptozotocin-diabetic male rats was decreased from corresponding control values. Microsomal androstenedione 7alpha-hydroxylase activity was increased, while 16alpha-hydroxylase activity was decreased in the diabetic animals. The effects are similar to previously reported changes in the hepatic microsomal metabolism of aniline and aminopyrine, respectively, and suggest similar regulatory mechanisms. Insulin treatment of diabetic animals antagonized all abnormalities of androstenedione.
链脲佐菌素诱导的糖尿病雄性大鼠肝脏微粒体对雄烯二酮的总代谢量较相应的对照值有所降低。糖尿病动物的微粒体雄烯二酮7α-羟化酶活性增加，而16α-羟化酶活性降低。这些效应分别类似于先前报道的肝脏微粒体对苯胺和氨基比林代谢的变化，提示存在相似的调节机制。对糖尿病动物进行胰岛素治疗可拮抗雄烯二酮的所有异常情况。
