Altered metabolism of androstenedione by hepatic microsomes from streptozotocin-diabetic male rats.

The total metabolism of androstenedione by hepatic microsomes from streptozotocin-diabetic male rats was decreased from corresponding control values. Microsomal androstenedione 7alpha-hydroxylase activity was increased, while 16alpha-hydroxylase activity was decreased in the diabetic animals. The effects are similar to previously reported changes in the hepatic microsomal metabolism of aniline and aminopyrine, respectively, and suggest similar regulatory mechanisms. Insulin treatment of diabetic animals antagonized all abnormalities of androstenedione.