Department of Urology, Japan Organization of Occupational Health and Safety, Kanto Rosai Hospital, 1-1 Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki 211-8510, Japan.
Department of Public Health, Dokkyo Medical University School of Medicine, 880 Kitakobayashi, Mibu, Shimotsuga-gun, Tochigi 321-0293, Japan.
Genes (Basel). 2022 Feb 28;13(3):448. doi: 10.3390/genes13030448.
This study examined the effects of single-nucleotide polymorphisms (SNPs) on the development of bladder cancer, adding longest-held occupational and industrial history as regulators. The genome purified from blood was genotyped, followed by SNP imputation. In the genome-wide association study (GWAS), several patterns of industrial/occupational classifications were added to logistic regression models. The association test between bladder cancer development and the calculated genetic score for each gene region was evaluated (gene-wise analysis). In the GWAS and gene-wise analysis, the gliomedin gene satisfied both suggestive association levels of 10 in the GWAS and 10 in the gene-wise analysis for male bladder cancer. The expression of the gliomedin protein in the nucleus of bladder cancer cells decreased in cancers with a tendency to infiltrate and those with strong cell atypia. It is hypothesized that gliomedin is involved in the development of bladder cancer.
本研究考察了单核苷酸多态性（SNPs）对膀胱癌发展的影响，并将最长持有的职业和工业史作为调节剂。从血液中纯化的基因组进行基因分型，然后进行 SNP 推断。在全基因组关联研究（GWAS）中，几种工业/职业分类模式被添加到逻辑回归模型中。评估了膀胱癌发展与每个基因区域计算的遗传评分之间的关联测试（基因分析）。在 GWAS 和基因分析中，神经胶质蛋白基因在男性膀胱癌的 GWAS 和基因分析中均满足 10 的提示关联水平。膀胱癌细胞核中神经胶质蛋白的表达在具有浸润倾向和细胞异型性较强的癌症中减少。据推测，神经胶质蛋白参与了膀胱癌的发展。
