嗅神经母细胞瘤：重新评估颅内扩展和囊肿形成的模式
Olfactory Neuroblastoma: Re-Evaluating the Paradigm of Intracranial Extension and Cyst Formation.
作者信息
Dumont Rebecca A, Palma Diaz Miguel Fernando, Hsu William, Sepahdari Ali R
机构信息
Neuroradiology Section, Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Diagnostic Department, Division of Radiology, University Hospitals of Geneva, University of Geneva, 1205 Geneva, Switzerland.
出版信息
Diagnostics (Basel). 2022 Mar 1;12(3):614. doi: 10.3390/diagnostics12030614.
The purpose of the current study was to assess the prevalence of cyst formation at the brain-tumor interface in olfactory neuroblastoma. We used the UCLA patient-based Pathology and Radiology Head and Neck Database (UPP&R HAND) to identify the largest patient cohort reported to date with imaging and pathology data. Eighteen of thirty-one patients (58.1%) had evidence of intracranial extension on MRI, while four (22.0%) demonstrated cyst formation at the brain-tumor interface. The extent of intracranial extension was by far the strongest predictor for intracranial cyst formation, regardless of Hyams tumor grade, using a binary logistics regression model ( = 0.002) and ROC curve analysis (AUC 94.6%). Cyst formation at the brain-tumor interface was an uncommon imaging finding, and tends to occur with a larger component of intracranial tumor extension.
本研究的目的是评估嗅神经母细胞瘤脑肿瘤界面处囊肿形成的发生率。我们使用基于加州大学洛杉矶分校患者的病理学和放射学头颈数据库（UPP&R HAND）来识别迄今为止报告的拥有影像学和病理学数据的最大患者队列。31名患者中有18名（58.1%）在MRI上有颅内扩展的证据，而4名（22.0%）在脑肿瘤界面处显示有囊肿形成。使用二元逻辑回归模型（P = 0.002）和ROC曲线分析（AUC 94.6%），无论海姆斯肿瘤分级如何，颅内扩展的程度是颅内囊肿形成的最强预测因素。脑肿瘤界面处的囊肿形成是一种不常见的影像学表现，并且往往在颅内肿瘤扩展成分较大时出现。
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