Lee Annesse, Goldstein David P, Irish Jonathan, Gentili Fred, Perez-Ordonez Bayardo
Division of Otolaryngology-Head and Neck Surgery, McMaster University, Hamilton, Ontario, Canada.
Skull Base. 2007 Nov;17(6):405-7. doi: 10.1055/s-2007-986459.
Esthesioneuroblastoma is a rare malignant neoplasm arising from the olfactory epithelium. This tumor has a tendency to originate from one side of the nasal cavity or paranasal sinuses with frequent extension into the contralateral nasal cavity through direct invasion. A review of the literature reveals numerous case reports describing esthesioneuroblastoma with unilateral or bilateral involvement; however, there have been no known reports of bilateral noncontiguous (multifocal) esthesioneuroblastoma. We present a unique case of a patient diagnosed with two separate primary esthesioneuroblastomas who was managed with preoperative radiation followed by surgical resection of the tumor. This case illustrates that esthesioneuroblastoma must remain as part of the differential diagnosis for a multifocal, noncontiguous intranasal and paranasal sinus mass.
嗅神经母细胞瘤是一种起源于嗅上皮的罕见恶性肿瘤。该肿瘤倾向于起源于鼻腔或鼻窦的一侧，并常通过直接侵犯蔓延至对侧鼻腔。文献回顾显示，有大量病例报告描述了单侧或双侧受累的嗅神经母细胞瘤；然而，尚无双侧非连续性（多灶性）嗅神经母细胞瘤的报道。我们报告了一例独特病例，该患者被诊断为两个独立的原发性嗅神经母细胞瘤，先接受术前放疗，随后进行肿瘤手术切除。该病例表明，对于多灶性、非连续性的鼻内和鼻窦肿块，嗅神经母细胞瘤必须作为鉴别诊断的一部分。
