Augustine Dominic, Rao Roopa S, Surendra Lakshminarayana, Gupta Bharti, Yoithapprabhunath Thuckanaickenpalayam Ragunathan, Yadalam Pradeep Kumar, Mushtaq Shazia, Ahmed Zeeshan Hera, Patil Shankargouda
Department of Oral Pathology & Microbiology, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, MSR Nagar, Bengaluru 560054, India.
Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Shwajra Campus, Jazan 45142, Saudi Arabia.
Diagnostics (Basel). 2022 Mar 20;12(3):756. doi: 10.3390/diagnostics12030756.
The inductive effect of hyalinisation and its influence on the biologic behaviour of ameloblastoma variants represent a scarcely researched domain of oral pathology. The complexity of the induction effects within the odontogenic apparatus, with the involvement of both ectodermal and mesodermal tissues, is responsible for diverse histopathological characteristics, hyalinisation being the major feature. The present study aims to deduce for the first time the correlation between the severity of hyalinisation (SOH) and recurrence in three unicystic ameloblastoma (UA) variants, namely, intra-luminal (UA-IL), luminal (UA-L) and mural (UA-M). Retrospectively diagnosed archival cases of UA-IL ( = 08), UA-L ( = 22) and UA-M ( = 30) were assessed for SOH and its correlation with recurrence. A subgroup comparison (between UA-IL/UA-L and UA-M) was also performed. The clinical parameters of the patients were also analysed from files for clinicopathological correlation with recurrence. Results: sub-epithelial hyalinisation (SEH) significantly correlated with the recurrence of UA-L and UA-M ( = 0.001). When the histologic types (UA-L and UA-IL vs. UA-M) were grouped and the correlation of SOH with recurrence was checked, it was observed that both groups ( = 0.001) showed strong statistical correlation. UA-M lesions with multilocular radiolucency ( = 0.001) also showed significant correlation with recurrence. SOH can be a reliable histological predictor of recurrence and of aggressive biologic behaviour in UA. The present study shows a significant association of hyalinisation with the biologic behaviour of UA. Further studies with immunohistochemical investigations could validate the presence of hyalinisation and identify the origin of the hyalinised product in UAs.
玻璃样变的诱导效应及其对成釉细胞瘤不同变体生物学行为的影响，是口腔病理学中一个研究较少的领域。牙源性器官内诱导效应的复杂性，涉及外胚层和中胚层组织，导致了多样的组织病理学特征，其中玻璃样变是主要特征。本研究旨在首次推断三种单囊型成釉细胞瘤（UA）变体，即腔内型（UA-IL）、腔型（UA-L）和壁型（UA-M）中玻璃样变严重程度（SOH）与复发之间的相关性。对回顾性诊断的UA-IL（=08）、UA-L（=22）和UA-M（=30）存档病例进行SOH评估及其与复发的相关性分析。还进行了亚组比较（UA-IL/UA-L与UA-M之间）。从病历中分析患者的临床参数，以探讨其与复发的临床病理相关性。结果：上皮下玻璃样变（SEH）与UA-L和UA-M的复发显著相关（=0.001）。当将组织学类型（UA-L和UA-IL与UA-M）分组并检查SOH与复发的相关性时，发现两组（=0.001）均显示出很强的统计学相关性。具有多房性透射影的UA-M病变（=0.001）也与复发显著相关。SOH可以作为UA复发和侵袭性生物学行为的可靠组织学预测指标。本研究表明玻璃样变与UA的生物学行为存在显著关联。进一步的免疫组织化学研究可以验证玻璃样变的存在，并确定UA中玻璃样变产物的来源。
