Fetissof F, Bruandet P, Arbeille B, Penot J, Marboeuf Y, Le Roux J, Guilloteau D, Beaulieu J L
Am J Surg Pathol. 1986 Oct;10(10):702-10. doi: 10.1097/00000478-198610000-00006.
Two cases of calcitonin-producing carcinomas of the prostate are reported. Light microscopical, immunohistochemical, and ultrastructural investigations have been performed. These tumors displayed a remarkable dual, endocrine and common epithelial (exocrine), differentiation. However, they presented two different architectural growth patterns. Of particular interest, numerous calcitonin cells were immunocharacterized. In addition, the endocrine component could harbour carcinoembryonic antigen, serotonin, human chorionic gonadotrophin, and prostate-specific acid phosphatase immunoreactive cells. Ultrastructural analysis confirmed the presence of numerous endocrine cells. These findings are not unexpected, since calcitonin, serotonin, and human chorionic gonadotrophin immunoreactive cells are normal and constitutive inhabitants of prostate gland. In the current cases, calcitonin cells showed a strong carcinoembryonic antigen immunoreactivity, as observed also in thyroidal C-cells. This peculiar kind of prostatic carcinoma might be compared to certain thyroidal tumors of intermediate type coupling parafollicular and follicular differentiation.
本文报告了两例产生降钙素的前列腺癌病例。进行了光镜、免疫组化和超微结构研究。这些肿瘤表现出显著的双重分化，即内分泌和普通上皮（外分泌）分化。然而，它们呈现出两种不同的结构生长模式。特别值得注意的是，对大量降钙素细胞进行了免疫特征分析。此外，内分泌成分可能含有癌胚抗原、5-羟色胺、人绒毛膜促性腺激素和前列腺特异性酸性磷酸酶免疫反应性细胞。超微结构分析证实了大量内分泌细胞的存在。这些发现并不意外，因为降钙素、5-羟色胺和人绒毛膜促性腺激素免疫反应性细胞是前列腺的正常组成细胞。在当前病例中，降钙素细胞显示出强烈的癌胚抗原免疫反应性，甲状腺C细胞中也观察到这种情况。这种特殊类型的前列腺癌可能与某些兼具滤泡旁细胞和滤泡分化的中间型甲状腺肿瘤相比较。
