培养的人淋巴细胞中芳烃羟化酶的诱导性：重复性研究
Inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes: a study of repeatability.
作者信息
Fletcher K A, Evans D A, Canning M V
出版信息
J Med Genet. 1978 Jun;15(3):182-8. doi: 10.1136/jmg.15.3.182.
Abstract
Modifications to the method for estimating aryl hydrocarbon hydroxylase (AHH) activity in cultured human lymphocytes are described. Despite the improvements to the technique it was not possible to show significant 'repeatability' of values for AHH induction over a period of 2 weeks or more. Significant repeatability could be seen when a blood sample from each subject was split into duplicates. However, this level of repeatability was low when considered for quantitative genetics purposes. Possible reasons for the poor repeatability have been discussed.
摘要
本文描述了对培养的人淋巴细胞中芳烃羟化酶（AHH）活性估算方法的改进。尽管该技术有所改进，但在两周或更长时间内，AHH诱导值仍无法显示出显著的“可重复性”。当将每个受试者的血样分成两份时，可以看到显著的可重复性。然而，从数量遗传学的角度来看，这种可重复性水平较低。文中讨论了可重复性差的可能原因。
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