肺癌患者单核细胞中苯并(a)芘代谢增强及DNA加合物的形成
Enhanced benzo(a)pyrene metabolism and formation of DNA adducts in monocytes of patients with lung cancer.
作者信息
Rüdiger H W, Heisig V, Hain E
出版信息
J Cancer Res Clin Oncol. 1980;96(3):295-302. doi: 10.1007/BF00408102.
Abstract
The conversion of G[3H]benzo(a)pyrene to water-soluble material and to DNA adducts was determined in peripheral blood monocytes of 52 healthy male and female volunteers and 27 patients with lung cancer. Active smokers converted more benzpyrene to DNA-bound material than nonsmokers, but did not form significantly more water soluble material. Monocytes of lung cancer patients clearly formed more water soluble material than cells of the control group, and slightly more DNA adducts when only males are compared. This enhanced BP conversion of lung cancer patients is independent of smoking habits.
摘要
在52名健康男性和女性志愿者以及27名肺癌患者的外周血单核细胞中，测定了G[3H]苯并(a)芘向水溶性物质和DNA加合物的转化情况。与不吸烟者相比，主动吸烟者将更多的苯并芘转化为与DNA结合的物质，但形成的水溶性物质并没有显著增多。肺癌患者的单核细胞比对照组细胞明显形成更多的水溶性物质，仅比较男性时，形成的DNA加合物略多。肺癌患者这种增强的BP转化与吸烟习惯无关。
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