C60富勒烯对跟腱切断术诱导萎缩后大鼠比目鱼肌恢复的影响。
Effect of C Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy.
作者信息
Nozdrenko Dmytro, Prylutska Svitlana, Bogutska Kateryna, Nurishchenko Natalia Y, Abramchuk Olga, Motuziuk Olexandr, Prylutskyy Yuriy, Scharff Peter, Ritter Uwe
机构信息
Department of Biophysics and Medical Informatics, ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Department of Physiology, Plant Biochemistry and Bioenergetics, Faculty of Plant Protection, Biotechnology and Ecology, National University of Life and Environmental Science of Ukraine, 03041 Kyiv, Ukraine.
出版信息
Life (Basel). 2022 Feb 23;12(3):332. doi: 10.3390/life12030332.
Biomechanical and biochemical changes in the muscle soleus of rats during imitation of hind limbs unuse were studied in the model of the Achilles tendon rupture (Achillotenotomy). Oral administration of water-soluble C fullerene at a dose of 1 mg/kg was used as a therapeutic agent throughout the experiment. Changes in the force of contraction and the integrated power of the muscle, the time to reach the maximum force response, the mechanics of fatigue processes development, in particular, the transition from dentate to smooth tetanus, as well as the levels of pro- and antioxidant balance in the blood of rats on days 15, 30 and 45 after injury were described. The obtained results indicate a promising prospect for C fullerene use as a powerful antioxidant for reducing and correcting pathological conditions of the muscular system arising from skeletal muscle atrophy.
在跟腱断裂（跟腱切断术）模型中，研究了大鼠比目鱼肌在模拟后肢废用时的生物力学和生化变化。在整个实验过程中，口服剂量为1 mg/kg的水溶性C富勒烯作为治疗剂。描述了损伤后第15天、30天和45天大鼠肌肉收缩力和综合功率的变化、达到最大力反应的时间、疲劳过程发展的力学，特别是从齿状强直到平滑强直的转变，以及大鼠血液中促氧化和抗氧化平衡水平。所得结果表明，C富勒烯作为一种强大的抗氧化剂，在减少和纠正骨骼肌萎缩引起的肌肉系统病理状况方面具有广阔的应用前景。
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