C60 富勒烯对慢性酒精中毒大鼠收缩力学动力学的影响。
The effect of C fullerene on the mechanokinetics of contraction in chronically alcoholized rats.
作者信息
Motuziuk Olexandr, Nozdrenko Dmytro, Prylutska Svitlana, Vareniuk Igor, Bogutska Kateryna, Braniuk Serhii, Korotkyi Olexandr, Prylutskyy Yuriy, Ritter Uwe, Piosik Jacek
机构信息
Faculty of Biology and Forestry, Lesya Ukrainka Volyn National University, Lutsk, 43025, Ukraine.
Department of Biophysics and Medical Informatics, ESC "Institute of Biology and Medicine", Taras Shevchenko National University of Kyiv, Kyiv, 01601, Ukraine.
出版信息
Heliyon. 2023 Jul 27;9(8):e18745. doi: 10.1016/j.heliyon.2023.e18745. eCollection 2023 Aug.
The C fullerene effect (oral administration at a dose of 1 mg kg) on the selected biomechanical parameters of contraction, biochemical indicators of blood and muscle tissue as well as histological changes in rat muscle tissue after chronic alcoholization for 3, 6 and 9 months was studied in detail. Water-soluble C fullerenes were shown to reduce the pathological processes development in the muscle apparatus by an average of (35-40)%. In particular, they reduced the time occurrence of fatigue processes in muscle during the long-term development of alcoholic myopathy and inhibited oxidative processes in muscle, thereby preventing its degradation. These findings open up the possibility of using C fullerenes as potent antioxidants for the correction of the pathological conditions of the muscle system arising from alcohol intoxication.
详细研究了C富勒烯效应（剂量为1毫克/千克口服）对慢性酒精化3、6和9个月后大鼠肌肉组织收缩的选定生物力学参数、血液和肌肉组织的生化指标以及组织学变化的影响。结果表明，水溶性C富勒烯可使肌肉器官中的病理过程发展平均减少（35 - 40）%。特别是，它们减少了酒精性肌病长期发展过程中肌肉疲劳过程的发生时间，并抑制了肌肉中的氧化过程，从而防止其退化。这些发现为使用C富勒烯作为有效抗氧化剂来纠正酒精中毒引起的肌肉系统病理状况开辟了可能性。
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