Abu Zeid Isam M, Al-Asmari Khalid M, Altayb Hisham N, Al-Attar Atef M, Qahl Safa H, Alomar Mohammed Y
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Princess Dr. Najla Bint Saud Al-Saud Center for Excellence Research in Biotechnology, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia.
Life (Basel). 2022 Feb 28;12(3):350. doi: 10.3390/life12030350.
Malathion (MAL) is an insecticide that has been linked to reproductive system damage in both humans and animals. In the present investigation, the antitoxic effects of coffee and olive oils on MAL-induced testicular dysfunctions were evaluated. MAL-intoxicated rats were supplemented with coffee and olive oils (400 mg/kg) for 7 weeks. Exposure to MAL resulted in statistically altered antioxidant enzymes and histopathological findings of necrotic seminiferous tubules and spermatogenetic arrest in rats after seven weeks of treatment. The effects of MAL intoxication on physiological and histopathological changes were improved by the use of these oils. Murine double minute 2 (MDM2) was found to interact well with chlorogenic acid and oleuropein, two compounds from coffee and olive oils, respectively. Coffee oil and olive oil were found to be promising therapeutic agents for MAL-induced testicular toxicity and oxidative damage.
马拉硫磷（MAL）是一种杀虫剂，已被证明与人类和动物的生殖系统损伤有关。在本研究中，评估了咖啡油和橄榄油对MAL诱导的睾丸功能障碍的抗毒作用。给MAL中毒的大鼠补充咖啡油和橄榄油（400毫克/千克），持续7周。治疗7周后，暴露于MAL导致大鼠抗氧化酶发生统计学改变，出现坏死性生精小管和生精停滞的组织病理学表现。使用这些油可改善MAL中毒对生理和组织病理学变化的影响。发现小鼠双微体2（MDM2）分别与咖啡油和橄榄油中的两种化合物绿原酸和橄榄苦苷有良好的相互作用。咖啡油和橄榄油有望成为治疗MAL诱导的睾丸毒性和氧化损伤的药物。
