Alleviation of Malathion Toxicity Effect by L. Oil and L. Oil on Lipid Profile: Physiological and In Silico Study.

The community health plans commonly use malathion (MAL), an organophosphate pesticide (OP), to eliminate pathogenic insects. The objective of the present research is to evaluate the consequences of L. oil and L. oil on MAL-intoxicated male rats. Six equal groups of animals were used for conducting this study ( = 10). Animals in group one were designated as control, animals belonging to group two were exposed to MAL in the measure of hundred mg per kg BW (body weight) for forty-nine days (seven weeks), rats in the third and fourth groups were administered with 400 mg/kg BW of L. and L. oils, respectively, and the same amount of MAL as given to the second group. Groups five and six were administered with the same amount of L. oil and L. oil as given to group three. Exposure of rats to 100 mg/kg body weight of MAL resulted in statistical alteration of the serum lipid profile. A marked decline was noticed in the severe changes of these blood parameters when MAL-intoxicated rats were treated with L. oil and L. oil. Two compounds from L. oil (Chlorogenic acid) and L. oil (Oleuropein) demonstrated good interaction with xanthine oxidase (XO) and 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) enzymes that are associated with cholesterol production. The present study indicated that L. oil and L. oil could be considered prospective and potential healing agents against metabolic conditions induced by MAL.