Yen Yung-Chieh, Chiu Nan-Ying, Hwang Tzung-Jeng, Su Tung-Ping, Yang Yen-Kuang, Chen Cheng-Sheng, Li Cheng-Ta, Su Kuan-Pin, Lai Te-Jen, Chang Chia-Ming
Department of Psychiatry, E-Da Hospital, Kaohsiung 824, Taiwan.
School of Medicine, I-Shou University, Kaohsiung 824, Taiwan.
J Pers Med. 2022 Feb 26;12(3):359. doi: 10.3390/jpm12030359.
Cognitive dysfunction is associated with functional impairment of patients with Major Depressive Disorder (MDD). The goals were to explore the associated factors of cognitive impairment in MDD and to develop and validate a brief and culture-relevant questionnaire, the Taiwan Cognition Questionnaire (TCQ), among patients with MDD. This was a cross-sectional, multi-center observational study of MDD patients in Taiwan. Participants of Group 1 from 10 centers contributed to the validation of the TCQ by their response and sociodemographics. The participants of Group 2 from one center received an objective cognitive assessment for clarification of the relationship between the TCQ score and its associated factors. In Group 1, 493 participants were recruited. As for Group 2, an extra 100 participants were recruited. The global Cronbach's alpha for the TCQ was 0.908. According to the coordinates of the ROC curve, 9/10 was the ideal cut-off point. With the criteria, the sensitivity/specificity of the TCQ was 0.610/0.689. The TCQ score was positively associated with a history of being admitted to acute psychiatric care and the severity of depression and negatively associated with objective cognitive measures. The TCQ provides a reliable, valid, and convenient measure of subjective cognitive dysfunction in patients with MDD.
认知功能障碍与重度抑郁症（MDD）患者的功能损害有关。本研究旨在探讨MDD患者认知障碍的相关因素，并开发和验证一份简短且与文化相关的问卷——台湾认知问卷（TCQ）。这是一项针对台湾MDD患者的横断面、多中心观察性研究。来自10个中心的第1组参与者通过其回答和社会人口统计学数据对TCQ进行了验证。来自一个中心的第2组参与者接受了客观认知评估，以明确TCQ得分与其相关因素之间的关系。在第1组中，招募了493名参与者。在第2组中，又额外招募了100名参与者。TCQ的总体Cronbach's alpha系数为0.908。根据ROC曲线的坐标，9/10是理想的截断点。按照该标准，TCQ的敏感性/特异性为0.610/0.689。TCQ得分与急性精神科住院史及抑郁严重程度呈正相关，与客观认知指标呈负相关。TCQ为MDD患者主观认知功能障碍提供了一种可靠、有效且便捷的测量方法。
