阿司匹林加重性呼吸系统疾病患者体内促炎性类二十烷酸的局部和全身生成与对气传变应原的致敏呈负相关。
Local and Systemic Production of Pro-Inflammatory Eicosanoids Is Inversely Related to Sensitization to Aeroallergens in Patients with Aspirin-Exacerbated Respiratory Disease.
作者信息
Potaczek Daniel P, Trąd Gabriela, Sanak Marek, Garn Holger, Mastalerz Lucyna
机构信息
Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Biochemical Pharmacological Center (BPC), Philipps University of Marburg, 35043 Marburg, Germany.
2nd Department of Internal Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland.
出版信息
J Pers Med. 2022 Mar 11;12(3):447. doi: 10.3390/jpm12030447.
Aspirin-exacerbated respiratory disease (AERD) is characterized by overproduction of the pro-inflammatory eicosanoids. Although immunoglobulin E-mediated sensitization to aeroallergens is common among AERD patients, it does not belong to the defining disease characteristics. In this study of 133 AERD patients, we sought to find a relationship between sensitization to aeroallergens and local (leukotriene E, prostaglandin E and prostaglandin D) and/or systemic (leukotriene E) production of arachidonic acid metabolites. Interestingly, a negative association between pro-inflammatory eicosanoid levels in induced sputum supernatant or urine and sensitization to aeroallergens was observed. This inverse relationship might suggest the presence of a protective effect of atopic sensitization to aeroallergens against stronger local airway inflammation and higher systemic AERD-related inflammatory activity.
阿司匹林加重性呼吸系统疾病（AERD）的特征是促炎类二十烷酸过度产生。尽管免疫球蛋白E介导的对空气过敏原的致敏在AERD患者中很常见，但它不属于该疾病的定义性特征。在这项对133例AERD患者的研究中，我们试图找出对空气过敏原的致敏与花生四烯酸代谢产物的局部（白三烯E、前列腺素E和前列腺素D）和/或全身（白三烯E）产生之间的关系。有趣的是，在诱导痰上清液或尿液中的促炎类二十烷酸水平与对空气过敏原的致敏之间观察到负相关。这种反向关系可能表明对空气过敏原的特应性致敏对更强的局部气道炎症和更高的全身AERD相关炎症活动具有保护作用。
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