Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Comput Intell Neurosci. 2022 Mar 15;2022:1054299. doi: 10.1155/2022/1054299. eCollection 2022.
The aim of the study is mainly to study the subject of BoNT-A injection to improve IAH in rats undergoing abdominal angioplasty. The study problem in surgery, especially in ICU, burn, and trauma centers, intra-abdominal hypertension (IAH), and abdominal compartment syndrome (ACS) are common complications. At present, there are various treatments for IAH. The intramuscular injection of Botulinum toxin type A (BoNT-A) into the abdominal wall has received a lot of attention. Based on this, this study proposes a method for measuring abdominal pressure, applies BoNT-A to reduce abdominal pressure in the IAH state of abdominal wall angioplasty, and explores a way to increase the compliance of the abdominal wall under the premise of maintaining the sealing of the abdominal cavity, so as to realize the expansion of the abdominal cavity. A method is achieved to reduce intra-abdominal pressure and eliminate or alleviate ACS. The results of the experiment showed that when the rats in the control group were injected with the same amount of normal saline as the rats in the experimental group, the IAP was significantly higher than that in the experimental group ( < 0.05). This shows that BoNT-A increases the compliance of the abdominal wall while maintaining the closure of the abdominal cavity, thereby increasing the volume of the abdominal cavity and alleviating the state of IAH in rats.
本研究的主要目的是研究 BoNT-A 注射对接受腹部血管成形术的大鼠 IAH 的改善作用。在手术中，特别是在 ICU、烧伤和创伤中心，腹腔内高压（IAH）和腹腔间隔室综合征（ACS）是常见的并发症。目前，IAH 有多种治疗方法。肉毒杆菌毒素 A 型（BoNT-A）肌内注射已受到广泛关注。基于此，本研究提出了一种测量腹压的方法，应用 BoNT-A 降低腹壁血管成形术 IAH 状态下的腹压，并探讨了在维持腹腔密闭性的前提下增加腹壁顺应性的方法，以实现腹腔扩张，从而降低腹内压并消除或缓解 ACS。实验结果表明，对照组大鼠注射与实验组大鼠等量的生理盐水时，IAP 明显高于实验组（<0.05）。这表明 BoNT-A 在维持腹腔密闭性的同时增加了腹壁顺应性，从而增加了腹腔容量，缓解了大鼠的 IAH 状态。
