Unraveling the Pathophysiology of Obesity-Related Insulin Resistance-A Perspective on "Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required".
作者信息
Goossens Gijs H, Blaak Ellen E
机构信息
Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
出版信息
Function (Oxf). 2020 Oct 5;1(2):zqaa021. doi: 10.1093/function/zqaa021. eCollection 2020.
Abstract
摘要
相似文献
1
Unraveling the Pathophysiology of Obesity-Related Insulin Resistance-A Perspective on "Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required".解析肥胖相关胰岛素抵抗的病理生理学——评《脂肪组织炎症与肥胖诱导的胰岛素抵抗直接相关，而肠道菌群失调和线粒体功能障碍并非必需》
Function (Oxf). 2020 Oct 5;1(2):zqaa021. doi: 10.1093/function/zqaa021. eCollection 2020.
2
Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required.脂肪组织炎症与肥胖引起的胰岛素抵抗直接相关，而肠道菌群失调和线粒体功能障碍并非必需条件。
Function (Oxf). 2020 Aug 25;1(2):zqaa013. doi: 10.1093/function/zqaa013. eCollection 2020.
3
The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties.橄榄（Olea europaea L.）叶提取物在饮食诱导肥胖的小鼠中的代谢和血管保护作用与改善肠道微生物群落失调及其免疫调节特性有关。
Pharmacol Res. 2019 Dec;150:104487. doi: 10.1016/j.phrs.2019.104487. Epub 2019 Oct 11.
4
Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity.磷酸甘油酯由肠道菌群失调和炎症诱导，并有利于调节肥胖症中的脂肪组织重塑。
FASEB J. 2019 Apr;33(4):4741-4754. doi: 10.1096/fj.201801897R. Epub 2019 Jan 4.
5
Macrophage Polarization Mediated by Mitochondrial Dysfunction Induces Adipose Tissue Inflammation in Obesity.线粒体功能障碍介导的巨噬细胞极化诱导肥胖症脂肪组织炎症。
Int J Mol Sci. 2022 Aug 17;23(16):9252. doi: 10.3390/ijms23169252.
6
Gut microbiota mediates the protective effects of dietary β-hydroxy-β-methylbutyrate (HMB) against obesity induced by high-fat diets.肠道微生物群介导膳食 β-羟基-β-甲基丁酸（HMB）对高脂肪饮食诱导肥胖的保护作用。
FASEB J. 2019 Sep;33(9):10019-10033. doi: 10.1096/fj.201900665RR. Epub 2019 Jun 5.
7
MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice.丝裂原活化蛋白激酶激酶激酶8（TPL2/COT）影响肥胖诱导的脂肪组织炎症，对人和小鼠均无全身影响。
PLoS One. 2014 Feb 24;9(2):e89615. doi: 10.1371/journal.pone.0089615. eCollection 2014.
8
Deficiency of exchange protein directly activated by cAMP (EPAC)-1 in mice augments glucose intolerance, inflammation, and gut dysbiosis associated with Western diet.在小鼠中，环磷酸腺苷（cAMP）直接激活的交换蛋白 EPAC-1 缺乏会加剧与西方饮食相关的葡萄糖不耐受、炎症和肠道菌群失调。
Microbiome. 2022 Nov 4;10(1):187. doi: 10.1186/s40168-022-01366-0.
9
Obesity-induced insulin resistance and macrophage infiltration of the adipose tissue: A vicious cycle.肥胖诱导的胰岛素抵抗与脂肪组织中的巨噬细胞浸润：恶性循环。
J Diabetes Investig. 2019 Jan;10(1):29-31. doi: 10.1111/jdi.12918. Epub 2018 Sep 24.
10
Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation.巨噬细胞极低密度脂蛋白受体通过脂肪组织炎症介导肥胖诱导的胰岛素抵抗。
Nat Commun. 2017 Oct 20;8(1):1087. doi: 10.1038/s41467-017-01232-w.
引用本文的文献
1
An American Physiological Society cross-journal Call for Papers on "The Physiology of Obesity".美国生理学会跨期刊征集关于“肥胖生理学”的论文。
Am J Physiol Lung Cell Mol Physiol. 2022 Nov 1;323(5):L593-L602. doi: 10.1152/ajplung.00335.2022. Epub 2022 Oct 12.
2
Bariatric surgery for the management of type 2 diabetes mellitus-current trends and challenges: a review article.用于治疗2型糖尿病的减肥手术——当前趋势与挑战：一篇综述文章
Am J Transl Res. 2022 Feb 15;14(2):1160-1171. eCollection 2022.
本文引用的文献
1
Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required.脂肪组织炎症与肥胖引起的胰岛素抵抗直接相关，而肠道菌群失调和线粒体功能障碍并非必需条件。
Function (Oxf). 2020 Aug 25;1(2):zqaa013. doi: 10.1093/function/zqaa013. eCollection 2020.
2
Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver.心身代谢健康的性别二态性：脂肪组织、肌肉和肝脏的作用。
Nat Rev Endocrinol. 2021 Jan;17(1):47-66. doi: 10.1038/s41574-020-00431-8. Epub 2020 Nov 10.
3
Current metabolic perspective on malnutrition in obesity: towards more subgroup-based nutritional approaches?当前肥胖相关营养不良的代谢观点：是否应采取更多基于亚组的营养方法？
Proc Nutr Soc. 2020 Aug;79(3):331-337. doi: 10.1017/S0029665120000117. Epub 2020 Mar 3.
4
Gut microbial metabolites in obesity, NAFLD and T2DM.肥胖、非酒精性脂肪性肝病和 T2DM 中的肠道微生物代谢产物。
Nat Rev Endocrinol. 2019 May;15(5):261-273. doi: 10.1038/s41574-019-0156-z.
5
The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function.肥胖中的代谢表型：脂肪量、体脂分布与脂肪组织功能
Obes Facts. 2017;10(3):207-215. doi: 10.1159/000471488. Epub 2017 Jun 1.
6
Exposing the exposures responsible for type 2 diabetes and obesity.揭示导致 2 型糖尿病和肥胖的暴露因素。
Science. 2016 Oct 7;354(6308):69-73. doi: 10.1126/science.aaf5094.
7
Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease.肥胖诱导的脂肪组织微环境变化及其对心血管疾病的影响。
Circ Res. 2016 May 27;118(11):1786-807. doi: 10.1161/CIRCRESAHA.115.306885.
8
Targeting fatty acid metabolism to improve glucose metabolism.靶向脂肪酸代谢以改善葡萄糖代谢。
Obes Rev. 2015 Sep;16(9):715-57. doi: 10.1111/obr.12298. Epub 2015 Jul 16.
9
Obesity as a medical problem.肥胖作为一个医学问题。
Nature. 2000 Apr 6;404(6778):635-43. doi: 10.1038/35007508.
10
Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice.肥胖与糖尿病：导致小鼠出现糖尿病 - 肥胖综合征的两个突变基因。
Diabetologia. 1978 Mar;14(3):141-8. doi: 10.1007/BF00429772.
Zotero 插件