Ede Huseyin, Ahmed Hosameldin Salah Shabib Sayed, Mahfouz Ahmed Sobhy Hassan Ghonim, Rahhal Alaa Abdullah Ali, Haider Shabir Ali, Madni Naseer Ahmed, Alkhatib Mohammad Akl, Elshrif Hossin Mohamed, Al Yafei Sumaya Mehdar A Al-Saadi, Al Suwaidi Jassim Mohd, Al-Qahtani Awad A Razaq, Asaad Nidal Ahmad
Department of Cardiology, Hamad Medical Corporation Heart Hospital, Doha, Qatar.
Department of Pharmacology, Hamad Medical Corporation Heart Hospital, Doha, Qatar.
Heart Views. 2021 Oct-Dec;22(4):249-255. doi: 10.4103/HEARTVIEWS.HEARTVIEWS_10_21. Epub 2022 Feb 11.
The aim of this study was to investigate the relation of high-sensitive cardiac troponin T (hs-cTnT) elevation with characteristics of supraventricular tachycardia (SVT) episode (duration and maximum heart rate) and coronary computed tomography angiography (CCTA) findings in patients with SVT who presented to the emergency room with palpitation.
This retrospective, single-center, noninvasive study included all patients aged between 18 years and 65 years who presented to the emergency department due to narrow-complex SVT and underwent CCTA to rule out coronary artery disease (CAD) due to elevation of hs-cTnT and reverted back to sinus rhythm after intravenous adenosine. The first, second, and the maximum hs-cTnT levels were obtained from the database. The patients were classified into normal coronaries, nonobstructive CAD, and obstructive CAD according to findings of the CCTA. The findings of the groups were compared.
Eighty-five patients were enrolled in the study. Of them, 21 (26%) patients were female. Sixty-three patients (74%) had normal coronary arteries as per CCTA results, whereas 22 patients (22%) had nonobstructive CAD and two patients (2%) had obstructive CAD. The groups did not differ statistically in respect to hs-cTnT measurements, duration of the arrhythmia, and maximum heart rate at SVT episode. There was no significant statistical correlation between hs-cTnT and the study parameters except the maximum heart rate.
Cardiac troponins may increase in patients with paroxysmal SVT irrespective of the presence of coronary lesions, and the CCTA may not be an appropriate investigation in the differential diagnosis of paroxysmal SVT with elevated hs-cTnT.
本研究旨在探讨高敏心肌肌钙蛋白T(hs-cTnT)升高与因心悸就诊于急诊室的室上性心动过速(SVT)发作特征(持续时间和最大心率)以及冠状动脉计算机断层扫描血管造影(CCTA)结果之间的关系。
这项回顾性、单中心、非侵入性研究纳入了所有年龄在18岁至65岁之间因窄QRS波型SVT就诊于急诊科且因hs-cTnT升高接受CCTA以排除冠状动脉疾病(CAD)并在静脉注射腺苷后恢复窦性心律的患者。从数据库中获取首次、第二次和最高hs-cTnT水平。根据CCTA结果将患者分为冠状动脉正常、非阻塞性CAD和阻塞性CAD三组。比较三组的结果。
85例患者纳入本研究。其中,21例(26%)为女性。根据CCTA结果,63例患者(74%)冠状动脉正常,22例患者(22%)有非阻塞性CAD,2例患者(2%)有阻塞性CAD。三组在hs-cTnT测量值、心律失常持续时间和SVT发作时的最大心率方面无统计学差异。除最大心率外,hs-cTnT与研究参数之间无显著统计学相关性。
阵发性SVT患者的心肌肌钙蛋白可能升高,与冠状动脉病变无关,且CCTA可能不是诊断hs-cTnT升高的阵发性SVT的合适检查方法。