偏头痛与卵圆孔未闭封堵术的关联：一项系统评价与分析
Association of migraine with patent foramen ovale closure: A systematic review and -analysis.
作者信息
Wang Yan-Li, Wang Fang-Ze, Zhang Yuan, Jiang Jiwei, Jia Ziyan, Liu Xiangrong, Wang Jian, Xu Jun
机构信息
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
出版信息
Int J Cardiol Heart Vasc. 2022 Mar 18;39:100992. doi: 10.1016/j.ijcha.2022.100992. eCollection 2022 Apr.
BACKGROUND
The potential correlation between patent foramen ovale (PFO) and migraine has been previously reported, but whether PFO closure plays a role in reducing migraine burden has not reached an agreement.
METHOD
We searched PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Database, VIP Science Technology Periodical Database and China Biology Medicine Database (CBM) through September 30, 2021 to identify associations between PFO closure and outcome of migraine burden. The control groups consisted of drug treatment or sham procedure.
RESULT
Three randomized clinical trials (RCT) and 9 case-control studies were eligible for inclusion (1754 participants), of which 7 reported nonrecurrence of migraine, 4 reported reduced migraine-frequency and migraine-days, and 5 reported HIT-6 score and 4 reported MIDAS score. The mean (SD) age of participants was 40.68 (3.81) years and 1340 (76.39%) were women. PFO closure was significantly associated with a reduced risk of migraine-recurrence by 4.47 (95% CI, 2.94-6.80; I = 12%), frequency of migraine by 0.35 (95% CI, 0.17-0.53; I = 0%) and monthly migraine days by 0.28 (95% CI, 0.10-0.46), and decreased score of HIT-6 (SMD 1.23, 95 %CI 0.52-1.95, I = 93%).
CONCLUSION
Transcatheter PFO closure is significantly associated with burden reduction of migraine headache.
背景
先前已有报道卵圆孔未闭（PFO）与偏头痛之间可能存在关联，但PFO封堵术在减轻偏头痛负担方面是否起作用尚未达成共识。
方法
我们检索了截至2021年9月30日的PubMed、Embase、中国知网（CNKI）、万方数据库、维普科技期刊数据库和中国生物医学数据库（CBM），以确定PFO封堵术与偏头痛负担结局之间的关联。对照组包括药物治疗或假手术。
结果
三项随机临床试验（RCT）和九项病例对照研究符合纳入标准（1754名参与者），其中七项报告偏头痛未复发，四项报告偏头痛发作频率和天数减少，五项报告了HIT-6评分，四项报告了MIDAS评分。参与者的平均（标准差）年龄为40.68（3.81）岁，女性有1340名（76.39%）。PFO封堵术与偏头痛复发风险显著降低4.47相关（95%CI，2.94-6.80；I²=12%），偏头痛发作频率降低0.35（95%CI，0.17-0.53；I²=0%），每月偏头痛天数减少0.28（95%CI，0.10-0.46），HIT-6评分降低（标准化均数差1.23，95%CI 0.52-1.95，I²=93%）。
结论
经导管PFO封堵术与偏头痛负担减轻显著相关。
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