Cushley M J, Wee L H, Holgate S T
Br J Clin Pharmacol. 1986 Oct;22(4):487-90. doi: 10.1111/j.1365-2125.1986.tb02923.x.
Since platelet activation has been incriminated in the pathogenesis of asthma, we have investigated the effect of one of its major granule-derived mediators, 5-hydroxytryptamine (5-HT, serotonin) on airway calibre in normal (12), atopic non-asthmatic (12) and atopic asthmatic subjects (16). On separate days subjects inhaled increasing concentrations of 5-HT and methacholine, and airway response was measured as FEV1, Vmax30 and sGaw. All subjects bronchoconstricted with methacholine, geometric mean provocation concentrations causing a 20% fall in FEV1 (PCf20) for the normal, atopic non-asthmatic and atopic asthmatic subjects being 28.6, 18.3 and 0.71 mM respectively. In contrast, 5-HT up to a maximum concentration of 77 mM had no consistent effect on FEV1, Vmax30 or sGaw in any of the subject groups. Thus, in contrast to a variety of animals, 5-HT is unlikely to serve as a significant bronchoconstrictor mediator in man.
由于血小板活化被认为与哮喘的发病机制有关，我们研究了其主要颗粒衍生介质之一5-羟色胺（5-HT，血清素）对正常受试者（12名）、特应性非哮喘受试者（12名）和特应性哮喘受试者（16名）气道口径的影响。在不同的日子里，受试者吸入浓度递增的5-HT和乙酰甲胆碱，并将气道反应测量为第一秒用力呼气容积（FEV1）、最大呼气中期流速（Vmax30）和比气道传导率（sGaw）。所有受试者对乙酰甲胆碱均出现支气管收缩，正常受试者、特应性非哮喘受试者和特应性哮喘受试者导致FEV1下降20%的几何平均激发浓度（PCf20）分别为28.6、18.3和0.71 mM。相比之下，在任何受试者组中，高达最大浓度77 mM的5-HT对FEV1、Vmax30或sGaw均无一致影响。因此，与多种动物不同，5-HT不太可能是人类重要的支气管收缩介质。
