Joos G, Pauwels R, van der Straeten M
Department of Respiratory Diseases, University Hospital, Ghent, Belgium.
Thorax. 1987 Oct;42(10):779-83. doi: 10.1136/thx.42.10.779.
The neuropeptides substance P and neurokinin A are present in sensory airway nerves. Their effect on airway calibre was compared in six healthy non-smoking subjects and six asthmatic subjects. On separate days increasing concentrations (from 10(-9) to 10(-6) mol/ml) of each neuropeptide were administered by nebuliser and the airway response measured as change in specific airway conductance (sGaw). Substance P and neurokinin A caused no change in sGaw in the healthy subjects. Inhalation of substance P up to the highest concentration of 10(-6) mol/ml caused no change in sGaw in the asthmatic subjects. Neurokinin A, however, caused bronchoconstriction with a mean fall in sGaw of 48% (SEM 12%) after 5 x 10(-7) mol/ml. The onset of bronchoconstriction was rapid, but sGaw had returned to baseline values within one hour in all but one patient.
神经肽P物质和神经激肽A存在于气道感觉神经中。在6名健康非吸烟受试者和6名哮喘受试者中比较了它们对气道口径的影响。在不同的日子里，通过雾化器给予每种神经肽递增浓度（从10^(-9)到10^(-6)mol/ml），并将气道反应测量为比气道传导率（sGaw）的变化。P物质和神经激肽A在健康受试者中未引起sGaw的变化。在哮喘受试者中，吸入高达最高浓度10^(-6)mol/ml的P物质也未引起sGaw的变化。然而，神经激肽A在5×10^(-7)mol/ml后引起支气管收缩，sGaw平均下降48%（标准误12%）。支气管收缩起效迅速，但除一名患者外，所有患者的sGaw在1小时内均恢复到基线值。
