Department of Oral Diagnostics, School of Dentistry at Matsudo, Nihon University, Matsudo, Japan.
Oral Dis. 2023 Jul;29(5):2224-2229. doi: 10.1111/odi.14198. Epub 2022 Mar 31.
The objective of the present study was to explore the clinical characteristics of BP180NC16a autoantibody-positive mucous membrane pemphigoid.
Data from 22 patients were collected by retrospective chart review. For the detection of BP180NC16a autoantibody, a commercially available enzyme-linked immunosorbent assay or chemiluminescent enzyme immunoassay kit was used. The patients were classified into the following clinical phenotypes: low-risk patients who had lesions only in the oral mucosa or in the oral mucosa and skin and high-risk patients who had lesions in the oral mucosa and any of the following sites: the eyes, upper respiratory tract, or esophagus.
Eleven of the 22 patients (50%) were BP180NC16a-positive at the time of diagnosis. All the positive patients were in the low-risk group. There was a significant difference in the incidence of low-risk mucous membrane pemphigoid between BP180NC16a autoantibody-positive and BP180NC16a autoantibody-negative patients (p = 0.004). Patients' age, disease duration, and oral disease activity scores were not significantly different between the two groups.
BP180NC16a reactivity was associated with the clinical phenotype characterized by only oral mucosal lesions or combined oral mucosal and skin lesions. BP180NC16a autoantibody might be useful as a serum marker to predict low-risk mucous membrane pemphigoid.
本研究旨在探讨 BP180NC16a 自身抗体阳性黏膜性类天疱疮的临床特征。
通过回顾性病历分析收集了 22 名患者的数据。为了检测 BP180NC16a 自身抗体，使用了市售的酶联免疫吸附测定或化学发光酶免疫测定试剂盒。将患者分为以下临床表型：仅口腔黏膜或口腔黏膜和皮肤有病变的低危患者，以及口腔黏膜和以下任何部位有病变的高危患者：眼睛、上呼吸道或食管。
22 名患者中有 11 名（50%）在诊断时为 BP180NC16a 阳性。所有阳性患者均属于低危组。BP180NC16a 自身抗体阳性和 BP180NC16a 自身抗体阴性患者之间低危黏膜性类天疱疮的发生率存在显著差异（p=0.004）。两组患者的年龄、病程和口腔疾病活动评分无显著差异。
BP180NC16a 的反应性与仅口腔黏膜病变或口腔黏膜和皮肤联合病变的临床表型相关。BP180NC16a 自身抗体可能是预测低危黏膜性类天疱疮的有用血清标志物。
