Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University, Pune, India.
Department of Pharmaceutics and Pharmaceutical Technology, Institute Pharmacy, Nirma University, Ahmedabad, India.
Drug Dev Ind Pharm. 2021 Nov;47(11):1713-1732. doi: 10.1080/03639045.2022.2058531. Epub 2022 Apr 6.
The skin serves as the major organ in the targeted transdermal drug delivery system for many compounds. The microneedle acts as a novel technique to deliver drugs across the different layers of the skin, including the major barrier stratum corneum, in an effective manner. A microneedle array patch comprises dozens to hundreds of micron-sized needles with numerous structures and advantages resulting from their special and smart designs. The microneedle approach is much more advanced than conventional transdermal delivery pathways due to several benefits like minimally invasive, painless, self-administrable, and enhanced patient compliance. The microneedles are classified into hollow, solid, coated, dissolving, and hydrogel. Several polymers are used to fabricate microneedle, such as natural, semi-synthetic, synthetic, biodegradable, and swellable polymers. Researchers in the preparation of microneedles also explored the combinations of polymers. The safety of the polymer used in microneedle is a crucial aspect to prevent toxicity . Thus, this review aims to provide a detailed review of microneedles and mainly focus on the various polymers used in the fabrication of microneedles.
皮肤是许多化合物经皮靶向药物传递系统的主要器官。微针作为一种新的技术，可以有效地将药物递送到皮肤的不同层，包括主要的屏障角质层。微针阵列贴片由数十到数百个微米大小的针组成，具有许多结构和优势，这是由于其特殊和智能的设计。微针方法比传统的经皮给药途径更先进，因为它具有微创、无痛、自我管理和提高患者依从性等优点。微针分为空心、实心、涂层、溶解和水凝胶。几种聚合物被用于制造微针，如天然、半合成、合成、可生物降解和溶胀聚合物。研究人员在制备微针时还探索了聚合物的组合。用于微针的聚合物的安全性是防止毒性的一个关键方面。因此，本综述旨在详细介绍微针，并主要关注用于制造微针的各种聚合物。
