Li Haonan, Cui Jie, Zhang Tianyi, Lin Fengli, Zhang Guimin, Feng Zhong
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, People's Republic of China.
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People's Republic of China.
Int J Nanomedicine. 2024 Dec 3;19:12957-12973. doi: 10.2147/IJN.S487313. eCollection 2024.
As a type of transdermal drug delivery system (TDDS), Microneedles (MNs) have garnered significant attention from researchers due to their ability to penetrate the stratum corneum (SC) of the skin, enhance drug permeability and bioavailability, avoid first-pass metabolism, and cause minimal damage to the skin. This makes them particularly suitable for localized transdermal drug delivery. Dissolvable microneedles (DMNs) can encapsulate sensitive particles, provide high drug-loading capacity, and possess biodegradability and biocompatibility, attracting extensive research interest. Chitosan (CS) has been selected as the matrix for manufacturing DMNs due to its excellent properties, including not eliciting an immune response in vivo and having active functional groups such as hydroxyl and amino groups that allow for modifications to impart appropriate mechanical strength and functionality to DMNs for specific applications. This paper provides a comprehensive review of the research status of various chitosan-based microneedles (CSMNs), explores the mechanisms of their dissolution in vivo, and discusses their applications in promoting wound healing, delivering macromolecular drugs, vaccine delivery, and anti-tumor therapies.
作为一种透皮给药系统（TDDS），微针（MNs）因其能够穿透皮肤角质层（SC）、提高药物渗透性和生物利用度、避免首过代谢以及对皮肤造成最小损伤的能力而受到研究人员的广泛关注。这使得它们特别适用于局部透皮给药。可溶解微针（DMNs）可以封装敏感颗粒，具有高载药量，并具有生物可降解性和生物相容性，吸引了广泛的研究兴趣。壳聚糖（CS）因其优异的性能被选作制造DMNs的基质，这些性能包括在体内不引发免疫反应以及具有羟基和氨基等活性官能团，这些官能团允许进行修饰，以便为特定应用赋予DMNs适当的机械强度和功能。本文全面综述了各种基于壳聚糖的微针（CSMNs）的研究现状，探讨了它们在体内的溶解机制，并讨论了它们在促进伤口愈合、递送大分子药物、疫苗递送和抗肿瘤治疗中的应用。
