Khader Georgia Arla Cabrera, Barboza Andressa da Silva, Ribeiro Juliana Silva, Ferreira Monika Lamas, Cuevás-Suarez Carlos Enrique, Piva Evandro, Lund Rafael Guerra
Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, Brazil.
Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, San Agustín Tlaxiaca, Mexico.
Biofouling. 2022 Mar;38(3):250-259. doi: 10.1080/08927014.2022.2056032. Epub 2022 Mar 25.
This study sought to evaluate the physical and antimicrobial properties of a thermopolymerizable acrylic resin (PMMA) modified with metallic methacrylate monomers -zirconia (ZM), tin (TM), and di-n-butyl (DNTMB) methacrylates. Color stability was evaluated before and after immersion of samples in a staining solution by a digital spectrophotometer. The mechanical brushing test was evaluated by the roughness test. The flexural strength test used a mechanical testing machine. Human keratinocytes were used to assess cell viability and the biofilm formation assay was carried out for 5 days, in a microcosms model after one year of specimen storage. For statistical analysis, the method chosen was based on adherence to the normal distribution model and equality of variances ( < 0.05). The addition of DNTMB to PMMA promoted great antimicrobial action, acceptable cytocompatibility, without hampering the physical-mechanical properties of the commercial material. Therefore, the modified PMMA proved to be a promisor alternative to conventional resins.This study sought to evaluate the physical and antimicrobial properties of a thermopolymerizable acrylic resin (PMMA) modified with metallic methacrylate monomers -zirconia (ZM), tin (TM), and di-n-butyldimethacrylate-tin (DNTMB) methacrylates. Color stability was evaluated before and after immersion of samples in a staining solution using a digital spectrophotometer. The mechanical brushing test was evaluated by the roughness test. The flexural strength test used a mechanical testing machine. Human keratinocytes were used to assess cell viability and the biofilm formation assay was carried out for 5 days in a microcosm model after one year of specimen storage. For statistical analysis, the method chosen was based on adherence to the normal distribution model and equality of variances ( < 0.05). The addition of DNTMB to PMMA promoted great antimicrobial action, acceptable cytocompatibility, without hampering the physical-mechanical properties of the commercial material. Therefore, the modified PMMA proved to be a promising alternative to conventional denture base resins for dental use.
本研究旨在评估用金属甲基丙烯酸酯单体——氧化锆（ZM）、锡（TM）和二正丁基甲基丙烯酸酯（DNTMB）改性的热聚合丙烯酸树脂（聚甲基丙烯酸甲酯，PMMA）的物理性能和抗菌性能。通过数字分光光度计评估样品在染色溶液中浸泡前后的颜色稳定性。通过粗糙度测试评估机械刷牙试验。弯曲强度测试使用机械试验机。使用人角质形成细胞评估细胞活力，并在标本储存一年后的微观模型中进行5天的生物膜形成试验。对于统计分析，所选择的方法基于对正态分布模型的拟合和方差齐性（<0.05）。向PMMA中添加DNTMB可促进强大的抗菌作用，具有可接受的细胞相容性，且不妨碍商业材料的物理机械性能。因此，改性PMMA被证明是传统牙科树脂的一种有前景的替代品。本研究旨在评估用金属甲基丙烯酸酯单体——氧化锆（ZM）、锡（TM）和二正丁基二甲基丙烯酸锡（DNTMB）改性的热聚合丙烯酸树脂（PMMA）的物理性能和抗菌性能。使用数字分光光度计评估样品在染色溶液中浸泡前后的颜色稳定性。通过粗糙度测试评估机械刷牙试验。弯曲强度测试使用机械试验机。使用人角质形成细胞评估细胞活力，并在标本储存一年后的微观模型中进行5天的生物膜形成试验。对于统计分析，所选择的方法基于对正态分布模型的拟合和方差齐性（<0.05）。向PMMA中添加DNTMB可促进强大的抗菌作用，具有可接受的细胞相容性，且不妨碍商业材料的物理机械性能。因此，改性PMMA被证明是牙科用传统义齿基托树脂的一种有前景的替代品。
