Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Department of Pancreato-thyroidic Surgery, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
J Magn Reson Imaging. 2022 Dec;56(6):1769-1780. doi: 10.1002/jmri.28158. Epub 2022 Mar 25.
The feasibility and reproducibility of multifrequency MR elastography (MRE) for diagnosing pancreatic ductal adenocarcinoma (PDAC) have not been reported.
To determine the feasibility and reproducibility of multifrequency MRE for assessing pancreatic stiffness in healthy and diseased pancreases.
Prospective.
A total of 40 healthy volunteers and 10 patients with PDAC were prospectively recruited between March 2018 and October 2021.
FIELD STRENGTH/SEQUENCE: A 3.0-T pancreatic MRE at frequencies in the order of 30, 40, 60, 80, and 100 Hz.
Body mass index (BMI) and wave distance of the healthy pancreas and PDAC were measured. Image quality was assessed using the image quality score (IQS: 1-4, ≥3 were considered diagnostic quality). Three readers independently performed the pancreatic stiffness and IQS assessments to evaluate reproducibility.
Logistic regression analyses were performed to determine variables that influenced IQS. Statistical significance was set at P <0.05. Levels of inter- and intrarater agreement were assessed using intraclass correlation coefficients (ICC) and Cohen's kappa coefficient (κ). Good reproducibility was set at ICC and κ ≥ 0.8.
In logistic regression analysis, a diagnostic IQS in healthy volunteers was independently associated with a lower BMI (odds ratio [OR] = 0.89 kg/m ), shorter wave distance (OR = 0.70 cm ), and lower frequency (30 and 40 Hz: OR = 170.01 and 96.02). In PDAC, frequency was the only independent factor for diagnostic IQS (30-60 Hz: OR = 46.18, 46.18, and 17.20, respectively) with 100 Hz as a reference. In healthy volunteers, good reproducibility was observed at 30 and 40 Hz. In PDAC, good reproducibility was observed at 30-60 Hz.
MRE at 30 and 40 Hz provides diagnostic wave images and reliable measurements of pancreatic stiffness in healthy volunteers. MRE at 30-60 Hz is acceptable for PDACs (IQS ≥ 3, ICC and κ ≥ 0.80).
1 TECHNICAL EFFICACY: Stage 2.
多频磁共振弹性成像（MRE）诊断胰腺导管腺癌（PDAC）的可行性和可重复性尚未见报道。
评估多频 MRE 评估健康和患病胰腺弹性的可行性和可重复性。
前瞻性。
2018 年 3 月至 2021 年 10 月期间，共前瞻性招募了 40 名健康志愿者和 10 名 PDAC 患者。
磁场强度/序列：3.0T 胰腺 MRE，频率依次为 30、40、60、80 和 100Hz。
测量健康胰腺和 PDAC 的体重指数（BMI）和波距。使用图像质量评分（IQS：1-4，≥3 为诊断质量）评估图像质量。三位读者独立进行胰腺硬度和 IQS 评估，以评估可重复性。
采用逻辑回归分析确定影响 IQS 的变量。P 值<0.05 为有统计学意义。采用组内相关系数（ICC）和 Cohen's kappa 系数（κ）评估组内和组间一致性水平。ICC 和 κ≥0.8 为具有良好的可重复性。
在逻辑回归分析中，健康志愿者中具有诊断质量的 IQS 与较低的 BMI（优势比[OR] = 0.89kg/m ）、较短的波距（OR = 0.70cm ）和较低的频率（30 和 40Hz：OR = 170.01 和 96.02）独立相关。在 PDAC 中，频率是诊断 IQS 的唯一独立因素（30-60Hz：OR = 46.18、46.18 和 17.20），以 100Hz 为参考。在健康志愿者中，30 和 40Hz 时具有良好的可重复性。在 PDAC 中，30-60Hz 时具有良好的可重复性。
30 和 40Hz 的 MRE 可提供诊断性波图像，并可可靠测量健康志愿者的胰腺硬度。30-60Hz 的 MRE 适用于 PDAC（IQS≥3，ICC 和 κ≥0.80）。
1 级技术功效：2 级。
