Lilford R J
Clin Obstet Gynaecol. 1986 Sep;13(3):611-32.
Chorion villus biopsy answers the pressing need for early prenatal diagnosis. The technique is carried out at about 10 weeks gestation and in most instances this tissue is amenable to direct analysis without culture. This technique is particularly suitable for gene probe diagnosis. However, it is now widely offered for cytogenetic diagnosis on the basis of maternal age and some 10 000 patients have been reported to a Central Registry. The procedure-related abortion rate in skilled hands would seem to be about 2-3%, although this is probably lower with the new transabdominal route. Despite the great deal of attention which is focused on this technique, it is still too early to tell whether chorion villus biopsy will replace amniocentesis as the standard method of prenatal diagnosis.
绒毛膜绒毛取样满足了早期产前诊断的迫切需求。该技术在妊娠约10周时进行，在大多数情况下，这种组织无需培养即可直接进行分析。这项技术特别适用于基因探针诊断。然而，基于孕妇年龄，现在广泛提供该技术用于细胞遗传学诊断，并且已有约10000名患者被报告至中央登记处。在技术熟练的情况下，与该操作相关的流产率似乎约为2% - 3%，不过采用新的经腹途径时流产率可能更低。尽管这项技术受到了大量关注，但现在判断绒毛膜绒毛取样是否会取代羊膜穿刺术成为产前诊断的标准方法还为时过早。
