Kt Ramya Devi, Karthick Dharshene, Saravanaraj Kirtikesav Salem, Jaganathan M K, Ghorai Suvankar, Hemdev Sanjana Prakash
Department of Biotechnology, School of Bioengineering, Faculty of Engineering and Technology, SRM Institute of Science and Technology, Tamil Nadu, India.
Department of Microbiology, Raiganj University, Uttar Dinajpur, India.
Cancer Invest. 2022 Sep;40(8):700-709. doi: 10.1080/07357907.2022.2057526. Epub 2022 May 12.
Pancreatic Ductal Adenocarcinoma (PDAC) has a poor patient survival rate in comparison with other cancer types, even after targeted therapy, chemotherapy, and immunotherapy. Therefore, a great deal needs to be done to gain a better understanding of the biology and identification of prognostic and predictive markers for the development of superior therapies. The microRNAs (miRNAs) belong to small non-coding RNAs that regulate post-transcriptional gene expression. Several shreds of evidence indicate that miRNAs play an important role in the pathogenesis of pancreatic cancer. Here we review the recent developments in miRNAs and their target role in the development, metastasis, migration, and invasion.
与其他癌症类型相比，胰腺导管腺癌（PDAC）患者的生存率较低，即使在接受靶向治疗、化疗和免疫治疗后也是如此。因此，需要做大量工作来更好地了解其生物学特性，并确定用于开发更优疗法的预后和预测标志物。微小RNA（miRNA）属于调控转录后基因表达的小型非编码RNA。有多项证据表明，miRNA在胰腺癌的发病机制中起重要作用。在此，我们综述了miRNA的最新研究进展及其在胰腺癌发生、转移、迁移和侵袭中的靶向作用。
