Burgess C D, Crane J, Graham A N, Maling T J
Clin Pharmacol Ther. 1986 Nov;40(5):550-3. doi: 10.1038/clpt.1986.222.
We have studied the hemodynamic effects of salbutamol and aminophylline in eight patients with obstructive airways disease. Aminophylline was administered intravenously as a bolus and an infusion for 150 minutes. Salbutamol was administered by nebulizer after 30 minutes and at the end of the infusion. Compared with placebo, salbutamol decreased ventricular afterload (decreased preinjection period and preinjection period to left ventricular ejection time ratio and diastolic blood pressure). Aminophylline decreased total electromechanical systole, corrected for heart rate, only (mean decrease -10.7 msec; range -6.5 to -15.1), indicating a mild positive inotropic effect. When both active treatments were combined, the effect on total electromechanical systole, corrected for heart rate, was potentiated (mean decrease -23.3 msec; range -19.1 to -33.1). Neither aminophylline nor the combination affected heart rate or blood pressure, suggesting no increase in myocardial oxygen consumption. The hemodynamic effects of aminophylline and salbutamol are potentiated in combination but are unlikely to be harmful in patients with obstructive airways disease.
我们研究了沙丁胺醇和氨茶碱对8例阻塞性气道疾病患者的血流动力学影响。氨茶碱以静脉推注和持续输注150分钟的方式给药。30分钟后及输注结束时通过雾化器给予沙丁胺醇。与安慰剂相比，沙丁胺醇降低了心室后负荷（降低了注射前期、注射前期与左心室射血时间比值以及舒张压）。氨茶碱仅降低了经心率校正的总电机械收缩期（平均降低-10.7毫秒；范围为-6.5至-15.1），表明有轻度正性肌力作用。当两种活性治疗联合使用时，对经心率校正的总电机械收缩期的作用增强（平均降低-23.3毫秒；范围为-19.1至-33.1）。氨茶碱及其联合用药均未影响心率或血压，提示心肌氧耗未增加。氨茶碱和沙丁胺醇联合使用时血流动力学作用增强，但对阻塞性气道疾病患者不太可能有害。
