非诺特罗与茶碱联合治疗可逆性慢性气流阻塞后的支气管扩张作用及血清茶碱水平
Bronchodilator effect and serum theophylline level after combined treatment with fenoterol and theophylline in reversible chronic airflow obstruction.
作者信息
Lucena M I, Almagro J, Rius F, Sanchez de la Cuesta F
机构信息
Department of Clinical Pharmacology, School of Medicine, Malaga, Spain.
出版信息
Eur J Clin Pharmacol. 1988;35(6):669-71. doi: 10.1007/BF00637605.
PMID:3234474
Abstract
Sustained-release theophylline 10.1 mg/kg b.d. was given with placebo of fenoterol 2.5 mg t.d.s. to 12 patients with chronic airway obstruction. Fenoterol did not significantly affect the steady state serum theophylline trough level (11.84 micrograms/ml for fenoterol vs 11.10 micrograms/ml for placebo). Addition of fenoterol produced no further increase in spirometric function nor in clinical status.
摘要
对12例慢性气道阻塞患者给予10.1毫克/千克体重的缓释茶碱，每日两次，同时给予2.5毫克的非诺特罗安慰剂，每日三次。非诺特罗对稳态血清茶碱谷浓度无显著影响（非诺特罗组为11.84微克/毫升，安慰剂组为11.10微克/毫升）。加用非诺特罗后，肺量计功能及临床状况均未进一步改善。
Zotero 插件