Friedmann Angeli José Pedro, Xavier da Silva Thamara Nishida, Schilling Bastian
Rudolf-Virchow-Zentrum Center for Integrative and Translational Bioimaginng, University of Würzburg, Würzburg, Germany.
Rudolf-Virchow-Zentrum Center for Integrative and Translational Bioimaginng, University of Würzburg, Würzburg, Germany.
Cancer Cell. 2022 Apr 11;40(4):346-348. doi: 10.1016/j.ccell.2022.03.003. Epub 2022 Mar 24.
In this issue of Cancer Cell, Liao et al. demonstrate that CD8 T cell-secreted interferon-gamma (IFN-γ) rewires cancer cell lipid metabolism via the enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4). ACSL4 activates polyunsaturated fatty acids and sensitizes cancer cells to ferroptosis in immunotherapy-relevant settings. These findings provide insights into how the metabolic and immune milieu could be used to promote ferroptosis.
在本期《癌细胞》杂志中，廖等人证明，CD8 T细胞分泌的γ干扰素（IFN-γ）通过酰基辅酶A合成酶长链家族成员4（ACSL4）改变癌细胞的脂质代谢。在免疫治疗相关环境中，ACSL4激活多不饱和脂肪酸并使癌细胞对铁死亡敏感。这些发现为如何利用代谢和免疫环境促进铁死亡提供了见解。
