Tang Shenglan, Chen Li
Department of the First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People's Republic of China.
Department of Obstetrics and Gynecology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, 261 Huansha Road, Shangcheng, Hangzhou, Zhejiang, 310006, People's Republic of China.
Cancer Cell Int. 2024 Oct 26;24(1):351. doi: 10.1186/s12935-024-03537-5.
Ovarian, endometrial, and cervical cancer are the most common types of gynecologic tumor in women. Surgery, combined with radiotherapy and chemotherapy, is commonly used to treat these tumors. Unfortunately, difficulties in early diagnosis and acquired drug resistance have resulted in poor outcomes for most patients. Ferroptosis is a form of regulated cell death that depends on iron and is characterized by iron accumulation, reactive oxygen species production, and lipid peroxidation. The strong association between ferroptosis and many diseases, especially tumor diseases, has been confirmed by numerous studies. Many studies have demonstrated that ferroptosis is involved in initiating, progressing and metastasizing gynecologic tumors. This review summarizes the pathogenesis of ferroptosis and its association with the development, treatment, and prognosis of gynecologic tumors, and further explore the potential utility of ferroptosis in treating gynecologic tumors.
卵巢癌、子宫内膜癌和宫颈癌是女性最常见的妇科肿瘤类型。手术联合放疗和化疗是治疗这些肿瘤的常用方法。不幸的是，早期诊断困难和获得性耐药导致大多数患者预后不佳。铁死亡是一种受调控的细胞死亡形式，依赖于铁，其特征是铁积累、活性氧生成和脂质过氧化。众多研究已证实铁死亡与许多疾病，尤其是肿瘤疾病之间存在密切关联。许多研究表明，铁死亡参与妇科肿瘤的发生、发展和转移。本文综述了铁死亡的发病机制及其与妇科肿瘤发生、治疗和预后的关系，并进一步探讨铁死亡在治疗妇科肿瘤中的潜在应用。
